Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device
AbstractTransport and mixing of minute amounts of biological fluids are significantly important in lab-on-a-chip devices. It has been shown that the electrothermal technique is a suitable candidate for applications involving high-conductivity biofluids, such as blood, saliva, and urine. Here, we introduce a double-array AC electrothermal (ACET) device consisting of two opposing microelectrode arrays, which can be used for simultaneous mixing and pumping. First, in a 2D simulation, an optimum electrode-pair configuration capable of achieving fast transverse mixing at a microfluidic channel cross-section is identified by comparing different electrode geometries. The results show that by adjusting the applied voltage pattern and position of the asymmetrical microelectrodes in the two arrays, due to the resultant circular flow streamlines, the time it takes for the analytes to be convected across the channel cross-section is reduced by 95% compared to a diffusion-only-based transport regime, and by 80% compared to a conventional two-layer ACET device. Using a 3D simulation, the fluid transport (pumping and mixing) capabilities of such an electrode pair placed at different angles longitudinally relative to the channel was studied. It was found that an asymmetrical electrode configuration placed at an angle in the range of
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Salari, A.; Dalton, C. Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device. Micromachines 2019, 10, 92.
Salari A, Dalton C. Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device. Micromachines. 2019; 10(2):92.Chicago/Turabian Style
Salari, Alinaghi; Dalton, Colin. 2019. "Simultaneous Pumping and Mixing of Biological Fluids in a Double-Array Electrothermal Microfluidic Device." Micromachines 10, no. 2: 92.
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