Next Article in Journal
Size Distribution Analysis with On-Chip Multi-Imaging Cell Sorter for Unlabeled Identification of Circulating Tumor Cells in Blood
Previous Article in Journal
Advances in Capacitive Micromachined Ultrasonic Transducers
Previous Article in Special Issue
From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle

Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application

1, 1,2,*, 1,2 and 1,2
1
College of Electronic and Information, Jiangsu University of Science and Technology, Zhenjiang 212003, China
2
Zhenjiang Laboratory of Information Sensing and Transmission Technology for Smart Ocean, Zhenjiang 212000, China
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(2), 153; https://doi.org/10.3390/mi10020153
Received: 29 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 23 February 2019
(This article belongs to the Special Issue Electronic Devices for Biomedical Applications)
  |  
PDF [3249 KB, uploaded 23 February 2019]
  |  

Abstract

Quartz crystal microbalance (QCM) is still a new high-precision surface detection technique. However, the adsorption quality detected by the QCM currently contains a solvent-coupling quality and cannot separate the actual biomolecular mass. Local surface plasmon resonance (LSPR) can detect the mass of biomolecules, but requires a certain contrast between the solvent of the surrounding medium and the refractive index of the adsorbed layer. The sensor chip, combining two compatible technologies, can realize the simultaneous detection of biomolecules and improve the refractive index sensitivity. The structure of our chip is to prepare the ring-shaped gold electrode on the upper surface of the quartz crystal, the circular gold electrode on the bottom surface, and the spherical gold nanoparticles arrays in the center region of the ring electrode to form a QCM/LSPR dual-technology chip. Through simulation, we finally get the size of the best energy trap by the two electrodes on the upper surface and the lower surface: the ring-top electrode with a thickness of 100 nm, an inner diameter of 4 mm, and an outer diameter of 8 mm; and the bottom electrode with a thickness of 100 nm and a radius of 6 mm. By comparing the refractive index sensitivity, we chose a spherical gold nanoparticle with a radius of 30 nm and a refractive sensitivity of 61.34 nm/RIU to design the LSPR sensor chip. View Full-Text
Keywords: gold nanoparticles; quartz crystal microbalance (QCM); local surface plasmon resonance (LSPR); gold electrode; dual-technology chip gold nanoparticles; quartz crystal microbalance (QCM); local surface plasmon resonance (LSPR); gold electrode; dual-technology chip
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ma, C.; Zhu, J.; Li, X.; Zheng, W. Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application. Micromachines 2019, 10, 153.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top