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Open AccessArticle

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

1
College of Mechanical and Electrical Engineering, Hohai University, Changzhou 213022, China
2
School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing 211189, China
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(12), 798; https://doi.org/10.3390/mi10120798 (registering DOI)
Received: 29 October 2019 / Revised: 16 November 2019 / Accepted: 20 November 2019 / Published: 21 November 2019
(This article belongs to the Collection Lab-on-a-Chip)
The microvalve for accurate flow control under low fluidic pressure is vital in cost-effective and miniaturized microfluidic devices. This paper proposes a novel microfluidic passive valve comprising of a liquid chamber, an elastic membrane, and an ellipsoidal control chamber, which actualizes a high flow rate control under an ultra-low threshold pressure. A prototype of the microvalve was fabricated by 3D printing and UV laser-cutting technologies and was tested under static and time-dependent pressure conditions. The prototype microvalve showed a nearly constant flow rate of 4.03 mL/min, with a variation of ~4.22% under the inlet liquid pressures varied from 6 kPa to 12 kPa. In addition, the microvalve could stabilize the flow rate of liquid under the time-varying sinusoidal pressures or the square wave pressures. To validate the functionality of the microvalve, the prototype microvalve was applied in a gas-driven flow system which employed an air blower or human mouth blowing as the low-cost gas source. The microvalve was demonstrated to successfully regulate the steady flow delivery in the system under the low driving pressures produced by the above gas sources. We believe that this new microfluidic passive valve will be suitable for controlling fluid flow in portable microfluidic devices or systems of wider applications. View Full-Text
Keywords: microfluidic; passive valve; ultra-low pressure; flow control; high flow rate microfluidic; passive valve; ultra-low pressure; flow control; high flow rate
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MDPI and ACS Style

Zhang, X.; Oseyemi, A.E. Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery. Micromachines 2019, 10, 798.

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