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Open AccessArticle

Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid

1
Department of Laboratory Medicine, College of Medicine, Korea University Guro Hospital, Korea University, Seoul 08308, Korea
2
Department of Emergency Medicine, College of Medicine, Korea University Guro Hospital, Korea University, Seoul 08308, Korea
3
Department of Medical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea
4
Department of Polymer Engineering, The University of Suwon, Hwaseong, Gyeonggi 18323, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Micromachines 2019, 10(12), 817; https://doi.org/10.3390/mi10120817
Received: 31 October 2019 / Revised: 23 November 2019 / Accepted: 25 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Microfluidics for Soft Matter and Mechanobiology )
Rapid and accurate identification of Candida albicans from among other candida species is critical for cost-effective treatment and antifungal drug assays. Shape is a critical biomarker indicating cell type, cell cycle, and environmental conditions; however, most microfluidic techniques have been focused only on size-based particle/cell manipulation. This study demonstrates a sheathless shape-based separation of particles/cells using a viscoelastic non-Newtonian fluid. The size of C. albicans was measured at 37 °C depending on the incubation time (0 h, 1 h, and 2 h). The effects of flow rates on the flow patterns of candida cells with different shapes were examined. Finally, 2-h-incubated candida cells with germ tube formations (≥26 μm) were separated from spherical candida cells and shorter candida cells with a separation efficiency of 80.9% and a purity of 91.2% at 50 μL/min. View Full-Text
Keywords: sheathless; viscoelastic fluid; separation; shape; Candida sheathless; viscoelastic fluid; separation; shape; Candida
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MDPI and ACS Style

Nam, J.; Jee, H.; Jang, W.S.; Yoon, J.; Park, B.G.; Lee, S.J.; Lim, C.S. Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid. Micromachines 2019, 10, 817.

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