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Open AccessArticle

Different Regimes of Opto-fluidics for Biological Manipulation

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Department of Chemical and Biomedical Engineering, University of South Florida, 4202 E. Fowler Ave, ENB118, Tampa, FL 33620, USA
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Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, 4202 E, Fowler Ave. ENB118, Tampa, FL 33620, USA
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Author to whom correspondence should be addressed.
Micromachines 2019, 10(12), 802; https://doi.org/10.3390/mi10120802
Received: 23 October 2019 / Revised: 13 November 2019 / Accepted: 19 November 2019 / Published: 21 November 2019
(This article belongs to the Special Issue Optofluidic Devices and Applications)
Metallic structures can be used for the localized heating of fluid and the controlled generation of microfluidic currents. Carefully designed currents can move and trap small particles and cells. Here we demonstrate a new bi-metallic substrate that allows much more powerful micro-scale manipulation. We show that there are multiple regimes of opto-fluidic manipulation that can be controlled by an external laser power. While the lowest power does not affect even small objects, medium power can be used for efficiently capturing and trapping particles and cells. Finally, the high-power regime can be used for 3D levitation that, for the first time, has been demonstrated in this paper. Additionally, we demonstrate opto-fluidic manipulation for an extraordinarily dynamic range of masses extending eight orders of magnitude: from 80 fg nano-wires to 5.4 µg live worms.
Keywords: opto-fluidics; micro-manipulation; cells; microparticles opto-fluidics; micro-manipulation; cells; microparticles
MDPI and ACS Style

Winskas, J.T.; Wang, H.; Zhdanov, A.; Cheemalapati, S.; Deonarine, A.; Westerheide, S.; Pyayt, A. Different Regimes of Opto-fluidics for Biological Manipulation. Micromachines 2019, 10, 802.

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