Exon Shuffling and Origin of Scorpion Venom Biodiversity
AbstractScorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a large number of ion channel-targeted neurotoxins with different folds, membrane-active antimicrobial peptides, proteases, and protease inhibitors. Although the biodiversity of scorpion venom has long been known, how it arises remains unsolved. In this work, we analyzed the exon-intron structures of an array of scorpion venom protein-encoding genes and unexpectedly found that nearly all of these genes possess a phase-1 intron (one intron located between the first and second nucleotides of a codon) near the cleavage site of a signal sequence despite their mature peptides remarkably differ. This observation matches a theory of exon shuffling in the origin of new genes and suggests that recruitment of different folds into scorpion venom might be achieved via shuffling between body protein-coding genes and ancestral venom gland-specific genes that presumably contributed tissue-specific regulatory elements and secretory signal sequences. View Full-Text
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Wang, X.; Gao, B.; Zhu, S. Exon Shuffling and Origin of Scorpion Venom Biodiversity. Toxins 2017, 9, 10.
Wang X, Gao B, Zhu S. Exon Shuffling and Origin of Scorpion Venom Biodiversity. Toxins. 2017; 9(1):10.Chicago/Turabian Style
Wang, Xueli; Gao, Bin; Zhu, Shunyi. 2017. "Exon Shuffling and Origin of Scorpion Venom Biodiversity." Toxins 9, no. 1: 10.
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