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Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

Natural Drug Discovery Group, School of Pharmacy, Queen’s University, Belfast BT9 7BL, Northern Ireland, UK
Fujian Provincial Institute for Food and Drug Quality Control, Fuzhou, Fujian 350000, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Bryan Grieg Fry
Toxins 2016, 8(7), 213;
Received: 14 May 2016 / Revised: 1 July 2016 / Accepted: 4 July 2016 / Published: 8 July 2016
(This article belongs to the Section Animal Venoms)
PDF [1880 KB, uploaded 8 July 2016]


Here we report the identification of a novel tryptophyllin-3 peptide with arterial smooth muscle relaxation activity from the skin secretion of the purple-sided leaf frog, Phyllomedusa baltea. This new peptide was named baltikinin and had the following primary structure, pGluDKPFGPPPIYPV, as determined by tandem mass spectrometry (MS/MS) fragmentation sequencing and from cloned skin precursor-encoding cDNA. A synthetic replicate of baltikinin was found to have a similar potency to bradykinin in relaxing arterial smooth muscle (half maximal effective concentration (EC50) is 7.2 nM). These data illustrate how amphibian skin secretions can continue to provide novel potent peptides that act through functional targets in mammalian tissues. View Full-Text
Keywords: amphibian; peptide; smooth muscle; molecular cloning amphibian; peptide; smooth muscle; molecular cloning

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Shi, D.; Xi, X.; Wang, L.; Gao, Y.; Ma, C.; Chen, H.; Zhou, M.; Chen, T.; Shaw, C. Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea. Toxins 2016, 8, 213.

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