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Regulation of Toxin Production in Clostridium perfringens

Miyarisan Pharmaceutical Co., Ltd., 1-10-3, Kaminakazato, Kita-ku, Tokyo 114-0016, Japan
Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan
Author to whom correspondence should be addressed.
Academic Editors: Holger Barth, Harald Genth and Michel R. Popoff
Toxins 2016, 8(7), 207;
Received: 20 March 2016 / Accepted: 24 June 2016 / Published: 5 July 2016
PDF [541 KB, uploaded 5 July 2016]


The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. A complicated regulatory network of toxin genes has been reported that includes a two-component system for regulatory RNA and cell-cell communication. It is necessary to clarify the global regulatory system of these genes in order to understand and treat the virulence of C. perfringens. We summarize the existing knowledge about the regulatory mechanisms here. View Full-Text
Keywords: C. perfringens; regulatory network C. perfringens; regulatory network

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Ohtani, K.; Shimizu, T. Regulation of Toxin Production in Clostridium perfringens. Toxins 2016, 8, 207.

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