Next Article in Journal / Special Issue
Oxidative Stress-Related Transcription Factors in the Regulation of Secondary Metabolism
Previous Article in Journal
The Snake Venom Rhodocytin from Calloselasma rhodostoma— A Clinically Important Toxin and a Useful Experimental Tool for Studies of C-Type Lectin-like Receptor 2 (CLEC-2)
Previous Article in Special Issue
Diversity of Pea-Associated F. proliferatum and F. verticillioides Populations Revealed by FUM1 Sequence Analysis and Fumonisin Biosynthesis

Towards Systems Biology of Mycotoxin Regulation

Eastern Cereal & Oilseed Research Centre, Agriculture & Agri-Food Canada, Ottawa, ON K1A 0C6, Canada
Cereal Research Centre, Agriculture & Agri-Food Canada, Winnipeg, MB R3T 2M9, Canada
Author to whom correspondence should be addressed.
Toxins 2013, 5(4), 675-682;
Received: 25 February 2013 / Revised: 22 March 2013 / Accepted: 10 April 2013 / Published: 18 April 2013
Systems biology is a scientific approach that integrates many scientific disciplines to develop a comprehensive understanding of biological phenomena, thus allowing the prediction and accurate simulation of complex biological behaviors. It may be presumptuous to write about toxin regulation at the level of systems biology, but the last decade of research is leading us closer than ever to this approach. Past research has delineated multiple levels of regulation in the pathways leading to the biosynthesis of secondary metabolites, including mycotoxins. At the top of this hierarchy, the global or master transcriptional regulators perceive various environmental cues such as climatic conditions, the availability of nutrients, and the developmental stages of the organism. Information accumulated from various inputs is integrated through a complex web of signalling networks to generate the eventual outcome. This review will focus on adapting techniques such as chemical and other genetic tools available in the model system Saccharomyces cerevisiae, to disentangle the various biological networks involved in the biosynthesis of mycotoxins in the Fusarium spp. View Full-Text
Keywords: synthetic genetic array; Saccharomyces cerevisiae; mycotoxin; chemical genetics synthetic genetic array; Saccharomyces cerevisiae; mycotoxin; chemical genetics
Show Figures

Figure 1

MDPI and ACS Style

Subramaniam, R.; Rampitsch, C. Towards Systems Biology of Mycotoxin Regulation. Toxins 2013, 5, 675-682.

AMA Style

Subramaniam R, Rampitsch C. Towards Systems Biology of Mycotoxin Regulation. Toxins. 2013; 5(4):675-682.

Chicago/Turabian Style

Subramaniam, Rajagopal, and Christof Rampitsch. 2013. "Towards Systems Biology of Mycotoxin Regulation" Toxins 5, no. 4: 675-682.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop