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In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Secretion of Pertussis Toxin from Bordetella pertussis

Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA
Toxins 2021, 13(8), 574;
Received: 4 June 2021 / Revised: 12 August 2021 / Accepted: 16 August 2021 / Published: 18 August 2021
(This article belongs to the Special Issue Pertussis Toxin and Research on Pertussis Vaccine)
Production and secretion of pertussis toxin (PT) is essential for the virulence of Bordetella pertussis. Due to the large oligomeric structure of PT, transport of the toxin across bacterial membrane barriers represents a significant hurdle that the bacteria must overcome in order to maintain pathogenicity. During the secretion process, PT undergoes a two-step transport process. The first step involves transport of the individual polypeptide chains of PT across the inner membrane utilizing a generalized secretion pathway, most likely the bacterial Sec system. The second step involves the use of a specialized apparatus to transport the toxin across the outer membrane of the bacterial cell. This apparatus, which has been termed the Ptl transporter and which is unique to the PT secretion pathway, is a member of the type IV family of bacterial transporters. Here, the current understanding of the PT secretion process is reviewed including a description of the Ptl proteins that assemble to form the transporter, the general structure of type IV transporters, the known similarities and differences between canonical type IV substrate transport and Ptl-mediated transport of PT, as well as the known sequence of events in the assembly and secretion of PT. View Full-Text
Keywords: toxin secretion; type IV secretion; pertussis toxin toxin secretion; type IV secretion; pertussis toxin
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MDPI and ACS Style

Burns, D.L. Secretion of Pertussis Toxin from Bordetella pertussis. Toxins 2021, 13, 574.

AMA Style

Burns DL. Secretion of Pertussis Toxin from Bordetella pertussis. Toxins. 2021; 13(8):574.

Chicago/Turabian Style

Burns, Drusilla L. 2021. "Secretion of Pertussis Toxin from Bordetella pertussis" Toxins 13, no. 8: 574.

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