Review Reports

Round 1

Reviewer 1 Report

In this review, authors well focalize normal homeostatic mechanisms maintaning tone and its pathophysiology. All paragraphs  are well organized and comprehensively described; review is scientifically sound and not misleading with appropriate and adequate references related and previous work. Moderate English changes required. So, I conclude work could be accept after minor English revision

Author Response

We thank the reviewer for the comment. We have edited some lines.

Reviewer 2 Report

Suggestions:

Line 27: Spasticity and rigidity, the two types/forms of hypertonia

Line 80: The anatomy underlying the regulation of muscle tone

Lines 393-4- Dystonia is not infrequently found in spinocerebellar ataxias, but rarely is it a  presenting symptom

Lines 395-6- SCA6 manifests as a pure cerebellar ataxia /as a pure ataxia phenotype; When present, dystonia cannot be explained (...)

Author Response

We thank the reviewer for the comments. He have edited the lines and have highlighted the changes.

1. Line 27: Spasticity and rigidity, the two types/forms of hypertonia

Ans: We have edited the line.

2. Line 80: The anatomy underlying the regulation of muscle tone

Ans: We have edited the line.

3. Lines 393-4- Dystonia is not infrequently found in spinocerebellar ataxias, but rarely is it a  presenting symptom

Ans: We have edited the line.

4. Lines 395-6- SCA6 manifests as a pure cerebellar ataxia /as a pure ataxia phenotype; When present, dystonia cannot be explained (...)

Ans: We have edited the line.