Structural Basis of the Pore-Forming Toxin/Membrane Interaction
1
Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
2
Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, School of Basic Medical Sciences, University of Science and Technology of China, Hefei 230027, China
*
Authors to whom correspondence should be addressed.
Toxins 2021, 13(2), 128; https://doi.org/10.3390/toxins13020128
Received: 26 October 2020
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Revised: 13 January 2021
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Accepted: 2 February 2021
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Published: 9 February 2021
(This article belongs to the Special Issue Bacterial Toxins: Protein Folding and Membrane Interactions)
With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence factors of many pathogenic bacteria and constitute the most characterized classes of pore-forming proteins (PFPs). Recent studies revealed the structural basis of several PFTs, both as soluble monomers, and transmembrane oligomers. Upon interacting with host cells, the soluble monomer of bacterial PFTs assembles into transmembrane oligomeric complexes that insert into membranes and affect target cell-membrane permeability, leading to diverse cellular responses and outcomes. Herein we have reviewed the structural basis of pore formation and interaction of PFTs with the host cell membrane, which could add valuable contributions in comprehensive understanding of PFTs and searching for novel therapeutic strategies targeting PFTs and interaction with host receptors in the fight of bacterial antibiotic-resistance.
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Keywords:
pore-forming toxin; structure; membrane interaction
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MDPI and ACS Style
Li, Y.; Li, Y.; Mengist, H.M.; Shi, C.; Zhang, C.; Wang, B.; Li, T.; Huang, Y.; Xu, Y.; Jin, T. Structural Basis of the Pore-Forming Toxin/Membrane Interaction. Toxins 2021, 13, 128. https://doi.org/10.3390/toxins13020128
AMA Style
Li Y, Li Y, Mengist HM, Shi C, Zhang C, Wang B, Li T, Huang Y, Xu Y, Jin T. Structural Basis of the Pore-Forming Toxin/Membrane Interaction. Toxins. 2021; 13(2):128. https://doi.org/10.3390/toxins13020128
Chicago/Turabian StyleLi, Yajuan, Yuelong Li, Hylemariam M. Mengist, Cuixiao Shi, Caiying Zhang, Bo Wang, Tingting Li, Ying Huang, Yuanhong Xu, and Tengchuan Jin. 2021. "Structural Basis of the Pore-Forming Toxin/Membrane Interaction" Toxins 13, no. 2: 128. https://doi.org/10.3390/toxins13020128
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