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Review

Folding Control in the Path of Type 5 Secretion

1
Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, Université de Paris, LBPC-PM, CNRS, UMR7099, 75005 Paris, France
2
Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild pour le Développement de la Recherche Scientifique, 75005 Paris, France
Toxins 2021, 13(5), 341; https://doi.org/10.3390/toxins13050341
Received: 15 March 2021 / Revised: 4 May 2021 / Accepted: 5 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Bacterial Toxins: Protein Folding and Membrane Interactions)
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins, adhesins, enzymes) and include numerous virulence factors. Mechanistically, the T5SS has long been considered the simplest of secretion systems, due to the paucity of proteins required for its functioning. Still, despite more than two decades of study, the exact process by which T5SS substrates attain their final destination and correct conformation is not totally deciphered. Moreover, the recent addition of new sub-families to the T5SS raises additional questions about this secretion mechanism. Central to the understanding of type 5 secretion is the question of protein folding, which needs to be carefully controlled in each of the bacterial cell compartments these proteins cross. Here, the biogenesis of proteins secreted by the Type 5 secretion system is discussed, with a focus on the various factors preventing or promoting protein folding during biogenesis. View Full-Text
Keywords: secretion; folding; autotransporter; type 5 secretion system; intimin; invasin; two-partner secretion; trimeric autotransporter secretion; folding; autotransporter; type 5 secretion system; intimin; invasin; two-partner secretion; trimeric autotransporter
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MDPI and ACS Style

Dautin, N. Folding Control in the Path of Type 5 Secretion. Toxins 2021, 13, 341. https://doi.org/10.3390/toxins13050341

AMA Style

Dautin N. Folding Control in the Path of Type 5 Secretion. Toxins. 2021; 13(5):341. https://doi.org/10.3390/toxins13050341

Chicago/Turabian Style

Dautin, Nathalie. 2021. "Folding Control in the Path of Type 5 Secretion" Toxins 13, no. 5: 341. https://doi.org/10.3390/toxins13050341

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