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Open AccessArticle

Effects of Nutrient Limitation on the Synthesis of N-Rich Phytoplankton Toxins: A Meta-Analysis

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Department of Earth Sciences, Faculty of Geosciences, Utrecht University, Princetonlaan 8a, 3584 CB Utrecht, The Netherlands
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Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands
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Ecology & Biodiversity, Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
4
Biont Research, Abeelstraat 33, 3552 RC Utrecht, The Netherlands
5
Faculty of Science, The University of Sydney, Camperdown, Sydney, NSW 2050, Australia
*
Authors to whom correspondence should be addressed.
Toxins 2020, 12(4), 221; https://doi.org/10.3390/toxins12040221
Received: 13 February 2020 / Revised: 11 March 2020 / Accepted: 12 March 2020 / Published: 1 April 2020
(This article belongs to the Special Issue Environmental Drivers of Algal and Cyanobacterial Toxin Dynamics)
Eutrophication has played a major role in the worldwide increase of harmful algal blooms (HABs). Higher input of key nutrients, such as nitrogen (N) and phosphorus (P), can stimulate the growth of harmful algal species in freshwater, estuarine, and coastal marine ecosystems. Some HAB-forming taxa, particularly several cyanobacteria and dinoflagellate species, are harmful through the production of N-rich toxins that have detrimental effects on the environment and human health. Here, we test how changes in nutrient availability affect N-rich toxin synthesis in cyanobacteria and dinoflagellates using a meta-analysis approach. Overall, N-rich toxin content showed an increase with P limitation, while it tended to decrease with N limitation, but we also observed substantial variation in responses both within and across genera and toxin groups. For instance, in response to N limitation, microcystin content varied from a 297% decrease up to a 273% increase, and paralytic shellfish poisoning (PSP) toxin content varied from a 204% decrease to an 82% increase. Cylindrospermopsin, produced by N2-fixing cyanobacteria, showed no clear direction in response to nutrient limitation, and cellular contents of this compound may thus vary independently of nutrient fluctuations. Our results confirm earlier reported stoichiometric regulation of N-rich phytoplankton toxins, showing increased toxin content with an increase in cellular N:P ratios, and vice versa. Thus, changes in N-rich toxin content largely follow the changes in relative cellular N content. Consequently, although nutrient limitation may limit bloom biomass and thereby bloom toxicity, our results warn that P limitation can cause accumulation of cellular toxins and thus lead to unexpected increases in bloom toxicity. View Full-Text
Keywords: harmful algal blooms; phycotoxins; eutrophication; stoichiometry; paralytic shellfish poisoning toxins; microcystin; cylindrospermopsin harmful algal blooms; phycotoxins; eutrophication; stoichiometry; paralytic shellfish poisoning toxins; microcystin; cylindrospermopsin
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Brandenburg, K.; Siebers, L.; Keuskamp, J.; Jephcott, T.G.; Van de Waal, D.B. Effects of Nutrient Limitation on the Synthesis of N-Rich Phytoplankton Toxins: A Meta-Analysis. Toxins 2020, 12, 221.

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