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Simple Diffusion as the Mechanism of Okadaic Acid Uptake by the Mussel Digestive Gland

1
Centro de Investigacións Mariñas (CIMA). Pedras de Corón, s/n. Apdo. 13, 36620 Vilanova de Arousa (Pontevedra), Spain
2
Instituto Español de Oceanografía, Centro Costero de Vigo, Subida a Radiofaro,50, 36390 San Miguel de Oia, Spain
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(7), 395; https://doi.org/10.3390/toxins11070395
Received: 14 May 2019 / Revised: 2 July 2019 / Accepted: 5 July 2019 / Published: 6 July 2019
(This article belongs to the Section Marine and Freshwater Toxins)
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PDF [2062 KB, uploaded 6 July 2019]
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Abstract

Okadaic acid (OA) and other toxins of the diarrheic shellfish poisoning (DSP) group are accumulated and transformed mainly in many bivalves, inside the digestive gland cells. In this work the absorption of okadaic acid by those cells has been studied by supplying the toxin dissolved in water and including it in oil droplets given to primary cell cultures, and by checking if the uptake is saturable and/or energy-dependent. Okadaic acid was found to be absorbed preferentially from the dissolved phase, and the uptake from oil droplets was substantially lower. The process did not require energy and was non-saturable, indicating that it involved a simple diffusion across the cellular membrane. Some apparent saturation was found due to the quick biotransformation of OA to 7-O-acyl esters. View Full-Text
Keywords: diffusion; digestive cells; absorption; okadaic acid; transport; endocytosis, okadaic acid; uptake diffusion; digestive cells; absorption; okadaic acid; transport; endocytosis, okadaic acid; uptake
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Blanco, J.; Martín, H.; Mariño, C.; Rossignoli, A.E. Simple Diffusion as the Mechanism of Okadaic Acid Uptake by the Mussel Digestive Gland. Toxins 2019, 11, 395.

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