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Dianthin and Its Potential in Targeted Tumor Therapies

Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, 13353 Berlin, Germany
Toxins 2019, 11(10), 592; https://doi.org/10.3390/toxins11100592
Received: 23 September 2019 / Accepted: 3 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Ribosome inactivating proteins (RIPs))
Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety. Dianthin-30 is very similar to saporin-S3 and saporin-S6, two RIPs often used to design targeted toxins for tumor therapy and already tested in some clinical trials. Nevertheless, dianthin enzymes also exhibit differences to saporin with regard to structure, efficacy, toxicity, immunogenicity and production by heterologous expression. Some of the distinctions might make dianthin more suitable for targeted tumor therapies than other RIPs. The present review provides an overview of the history of dianthin discovery and illuminates its structure, function and role in targeted toxins. It further discusses the option to increase the efficacy of dianthin by endosomal escape enhancers. View Full-Text
Keywords: dianthin; ribosome-inactivating protein; targeted toxin; immunotoxin; endosomal escape; cancer therapy; Dianthus caryophyllus L. dianthin; ribosome-inactivating protein; targeted toxin; immunotoxin; endosomal escape; cancer therapy; Dianthus caryophyllus L.
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Fuchs, H. Dianthin and Its Potential in Targeted Tumor Therapies. Toxins 2019, 11, 592.

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