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Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes

1
Department of Physics, IBILCE, São Paulo State University, São José do Rio Preto, SP 15054-000, Brazil
2
Immunopathology Laboratory, Butantan Institute, Sao Paulo, SP 05503-900, Brazil
3
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(10), 559; https://doi.org/10.3390/toxins11100559
Received: 31 July 2019 / Revised: 4 September 2019 / Accepted: 16 September 2019 / Published: 24 September 2019
(This article belongs to the Special Issue Arthropod Venom Components and Their Potential Usage)
Solitary wasps use their stinging venoms for paralyzing insect or spider prey and feeding them to their larvae. We have surveyed bioactive substances in solitary wasp venoms, and found antimicrobial peptides together with some other bioactive peptides. Eumenine mastoparan-AF (EMP-AF) was the first to be found from the venom of the solitary eumenine wasp Anterhynchium flavomarginatum micado, showing antimicrobial, histamine-releasing, and hemolytic activities, and adopting an α-helical secondary structure under appropriate conditions. Further survey of solitary wasp venom components revealed that eumenine wasp venoms contained such antimicrobial α-helical peptides as the major peptide component. This review summarizes the results obtained from the studies of these peptides in solitary wasp venoms and some analogs from the viewpoint of (1) chemical and biological characterization; (2) physicochemical properties and secondary structure; and (3) channel-like pore-forming properties. View Full-Text
Keywords: solitary wasp; venom; antimicrobial peptide; linear cationic α-helical peptide; amphipathic α-helix structure; channel-like pore-forming activity solitary wasp; venom; antimicrobial peptide; linear cationic α-helical peptide; amphipathic α-helix structure; channel-like pore-forming activity
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dos Santos Cabrera, M.P.; Rangel, M.; Ruggiero Neto, J.; Konno, K. Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes. Toxins 2019, 11, 559.

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