Next Article in Journal
Development and Validation of a UPLC-MS/MS and UPLC-HR-MS Method for the Determination of Fumonisin B1 and Its Hydrolysed Metabolites and Fumonisin B2 in Broiler Chicken Plasma
Next Article in Special Issue
G Protein α Subunit GpaB is Required for Asexual Development, Aflatoxin Biosynthesis and Pathogenicity by Regulating cAMP Signaling in Aspergillus flavus
Previous Article in Journal
Fatal Neurotoxicosis in Dogs Associated with Tychoplanktic, Anatoxin-a Producing Tychonema sp. in Mesotrophic Lake Tegel, Berlin
Previous Article in Special Issue
Comparative Response of the Hepatic Transcriptomes of Domesticated and Wild Turkey to Aflatoxin B1
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Toxins 2018, 10(2), 61; https://doi.org/10.3390/toxins10020061

Survey of Candidate Genes for Maize Resistance to Infection by Aspergillus flavus and/or Aflatoxin Contamination

1
USDA ARS Corn Host Plant Resistance Research Unit, Mississippi State, MS 39762, USA
2
USDA Forest Service, Forest Products Laboratory, Starkville, MS 39759, USA
3
Integrated Micro-Chromatography Systems LLC, Irmo, SC 29063, USA
4
Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Starkville, MS 39762 USA
5
Department of Plant and Soil Sciences, Mississippi State University, Starkville, MS 39762, USA
*
Author to whom correspondence should be addressed.
Received: 21 December 2017 / Revised: 20 January 2018 / Accepted: 24 January 2018 / Published: 31 January 2018
(This article belongs to the Collection Aflatoxins)
Full-Text   |   PDF [746 KB, uploaded 8 February 2018]   |  

Abstract

Many projects have identified candidate genes for resistance to aflatoxin accumulation or Aspergillus flavus infection and growth in maize using genetic mapping, genomics, transcriptomics and/or proteomics studies. However, only a small percentage of these candidates have been validated in field conditions, and their relative contribution to resistance, if any, is unknown. This study presents a consolidated list of candidate genes identified in past studies or in-house studies, with descriptive data including genetic location, gene annotation, known protein identifiers, and associated pathway information, if known. A candidate gene pipeline to test the phenotypic effect of any maize DNA sequence on aflatoxin accumulation resistance was used in this study to determine any measurable effect on polymorphisms within or linked to the candidate gene sequences, and the results are published here. View Full-Text
Keywords: maize; Zea mays L.; Aspergillus flavus; aflatoxin; candidate genes; Key Contribution; Quantitative trait loci associated with resistance to Aspergillus flavus and/or aflatoxin production can be quite large and are comprised of thousands of genes, thus making it difficult to determine which one(s) may be most relevant to pursue in breeding for improved resistance. The authors examined maize mapping populations for association of polymorphisms within 195 candidate genes that may be involved in resistance. Many of the identified candidates genes offer clues to key metabolic and/or enzymatic pathways that may have a significant effect on reducing fungal infection and/or aflatoxin accumulation. maize; Zea mays L.; Aspergillus flavus; aflatoxin; candidate genes; Key Contribution; Quantitative trait loci associated with resistance to Aspergillus flavus and/or aflatoxin production can be quite large and are comprised of thousands of genes, thus making it difficult to determine which one(s) may be most relevant to pursue in breeding for improved resistance. The authors examined maize mapping populations for association of polymorphisms within 195 candidate genes that may be involved in resistance. Many of the identified candidates genes offer clues to key metabolic and/or enzymatic pathways that may have a significant effect on reducing fungal infection and/or aflatoxin accumulation.
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Hawkins, L.K.; Warburton, M.L.; Tang, J.D.; Tomashek, J.; Alves Oliveira, D.; Ogunola, O.F.; Smith, J.S.; Williams, W.P. Survey of Candidate Genes for Maize Resistance to Infection by Aspergillus flavus and/or Aflatoxin Contamination. Toxins 2018, 10, 61.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top