Bariatric Surgery and Precision Nutrition
Abstract
:1. Introduction
2. Genetic Background and Bariatric Surgery Management
3. Epigenetic Signatures Related to Bariatric Surgery Outcomes
4. Bariatric Surgery and Gene Expression Profile
5. The Role of Bariatric Surgery on Microbiota
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
- Hao, Z.; Mumphrey, M.B.; Morrison, C.D.; Münzberg, H.; Ye, J.; Berthoud, H.R. Does gastric bypass surgery change body weight set point? Int. J. Obes. Suppl. 2016, 6, S37–S43. [Google Scholar] [CrossRef] [PubMed]
- Schauer, P.R.; Nor Hanipah, Z.; Rubino, F. Metabolic surgery for treating type 2 diabetes mellitus: Now supported by the world’s leading diabetes organizations. Clevel. Clin. J. Med. 2017, 84, S47–S56. [Google Scholar] [CrossRef] [PubMed]
- Busetto, L.; Dixon, J.; De Luca, M.; Shikora, S.; Pories, W.; Angrisani, L. Bariatric surgery in class I obesity: A position statement from the international federation for the surgery of obesity and metabolic disorders (IFSO). Obes. Surg. 2014, 24, 487–519. [Google Scholar] [CrossRef] [PubMed]
- Angrisani, L.; Santonicola, A.; Iovino, P.; Formisano, G.; Buchwald, H.; Scopinaro, N. Bariatric surgery world wide 2013. Obes. Surg. 2015, 25, 1822–1832. [Google Scholar] [CrossRef] [PubMed]
- Schauer, P.R.; Mingrone, G.; Ikramuddin, S.; Wolfe, B. Clinical outcomes of metabolic surgery: Efficacy of glycemic control, weight loss, and remission of diabetes. Diabetes Care 2016, 39, 902–911. [Google Scholar] [CrossRef] [PubMed]
- Khorgami, Z.; Andalib, A.; Corcelles, R.; Aminian, A.; Brethauer, S.; Schauer, P. Recent national trends in the surgical treatment of obesity: Sleeve gastrectomy dominates. Surg. Obes. Relat. Dis. 2015, 11, S1–S34. [Google Scholar] [CrossRef]
- Buchwald, H.; Avidor, Y.; Braunwald, E.; Jensen, M.D.; Pories, W.; Fahrbach, K.; Schoelles, K. Bariatric surgery: A systematic review and meta-analysis. JAMA 2004, 292, 1724–1737. [Google Scholar] [CrossRef] [PubMed]
- Nicoletti, C.F.; de Oliveira, B.A.P.; Pinhel, M.A.S.; Donati, B.; Marchini, J.S.; Salgado-Junior, W.; Nonino, C.B. Influence of excess weight loss and weight regain on biochemical indicators during a 4-year follow-up after Roux-en-Y gastric bypass. Obes. Surg. 2015, 25, 279–284. [Google Scholar] [CrossRef] [PubMed]
- Cooper, T.C.; Simmons, E.B.; Webb, K.; Burns, J.L.; Kushner, R.F. Trends in weight regain following Rouxen-Y gastric bypass (RYGB) bariatric surgery. Obes. Surg. 2015, 25, 1474–1481. [Google Scholar] [CrossRef] [PubMed]
- Magro, D.O.; Geloneze, B.; Delfini, R.; Pareja, B.C.; Callejas, F.; Pareja, J.C. Long-term weight regain after gastric bypass: A 5-year prospective study. Obes. Surg. 2008, 18, 648–651. [Google Scholar] [CrossRef] [PubMed]
- Still, C.D.; Wood, G.C.; Chu, X.; Erdman, R.; Manney, C.H.; Benotti, P.N.; Petrick, A.T.; Strodel, W.E.; Mirshahi, U.L.; Mirshahi, T.; et al. High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery. Obesity 2011, 19, 1676–1683. [Google Scholar] [CrossRef] [PubMed]
- Hainer, V.; Zamrazilova, H.; Spalova, J.; Hainerova, I.; Kunesova, M.; Aldhoon, B.; Bendlová, B. Role of hereditary factors in weight loss and its maintenance. Phys. Res. 2008, 57, S1–S15. [Google Scholar]
- Kashyap, S.R.; Gatmaitan, P.; Brethauer, S.; Schauer, P. Bariatric surgery for type 2 diabetes: Weighing the impact for obese patients. Clevel. Clin. J. Med. 2010, 77, 468–476. [Google Scholar] [CrossRef] [PubMed]
- De Luis, D.A.; Sagrado, M.G.; Pacheco, D.; Terroba, M.C.; Martin, T.; Cuellar, L.; Ventosa, M. Effect of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery. Surg. Obes. Relat. Dis. 2010, 6, 516–520. [Google Scholar] [CrossRef] [PubMed]
- Ferguson, L.R.; De Caterina, R.; Görman, U.; Allayee, H.; Kohlmeier, M.; Prasad, C.; Choi, M.S.; Curi, R.; de Luis, D.A.; Gil, Á.; et al. Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1—Fields of precision nutrition. J. Nutrigenet. Nutrigenom. 2016, 9, 12–27. [Google Scholar] [CrossRef] [PubMed]
- Kaput, J.; Astley, S.; Renkema, M.; Ordovas, J.; van Ommen, B. Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools. Genes Nutr. 2006, 1, 5–11. [Google Scholar] [CrossRef] [PubMed]
- Peña-Romero, A.C.; Navas-Carrillo, D.; Marín, F.; Orenes-Piñero, E. The future of nutrition: nutrigenomics and nutrigenetics in obesity and cardiovascular diseases. Crit. Rev. Food Sci. Nutr. 2017, 5. [Google Scholar] [CrossRef] [PubMed]
- Simopoulos, A.P. Nutrigenetics/nutrigenomics. Annu. Rev. Public Health 2010, 31, 53–68. [Google Scholar] [CrossRef] [PubMed]
- Martínez, J.A. Perspectives on personalized nutrition for obesity. Nutrigenet. Nutrigenom. 2014, 7. [Google Scholar] [CrossRef] [PubMed]
- Kovolou, G.D.; Kolovou, V.; Papadopoulou, A.; Watts, G.F. MTP gene variants and response to lomitapide in patients with homozygous familial hypercholesterolemia. J. Atheroscler. Thromb. 2016, 23, 878–883. [Google Scholar] [CrossRef] [PubMed]
- Resende, C.M.M.; Durso, D.F.; Borges, K.B.G.; Pereira, R.M.; Rodrigues, G.K.D.; Rodrigues, K.F.; Silva, J.L.P.; Rodrigues, E.C.; Franco, G.R.; Alvarez-Leite, J.I. The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months. Clin. Nutr. 2017. [Google Scholar] [CrossRef] [PubMed]
- Nicoletti, C.F.; de Oliveira, A.P.; Brochado, M.J.; Pinhel, M.A.; de Oliveira, B.A.; Marchini, J.S.; Dos Santos, J.E.; Salgado, W., Jr.; Cury, N.M.; de Araújo, L.F.; et al. The Ala55Val and −866G > A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass. Nutrition 2017, 33, 326–330. [Google Scholar] [CrossRef] [PubMed]
- De Luis, D.A.; Izaola, O.; Primo, D.; Pacheco, D. Effect of the rs10767664 Variant of the brain-derived neurotrophic factor gene on weight change and cardiovascular risk factors in morbidly obese patients after biliopancreatic diversion surgery. J. Nutrigenet. Nutrigenom. 2016, 9, 116–122. [Google Scholar] [CrossRef] [PubMed]
- Novais, P.F.; Weber, T.K.; Lemke, N.; Verlengia, R.; Crisp, A.H.; Rasera-Junior, I.; de Oliveira, M.R. Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women. Obes. Res. Clin. Pract. 2016, 10, 724–727. [Google Scholar] [CrossRef] [PubMed]
- Hartmann, I.B.; Fries, G.R.; Bücker, J.; Scotton, E.; von Diemen, L.; Kauer-Sant’Anna, M. The FKBP5 polymorphism rs1360780 is associated with lower weight loss after bariatric surgery: 26 months of follow-up. Surg. Obes. Relat. Dis. 2016, 12, 1554–1560. [Google Scholar] [CrossRef] [PubMed]
- Seip, R.L.; Papasavas, P.; Stone, A.; Thompson, S.; Ng, J.; Tishler, D.S.; Ruaño, G. Comparative physiogenomic analyses of weight loss in response to 2 modes of bariatric surgery: Demonstration with candidate neuropsychiatric and cardiometabolic genes. Surg. Obes. Relat. Dis. 2016, 12, 369–377. [Google Scholar] [CrossRef] [PubMed]
- Vitolo, E.; Santini, E.; Seghieri, M.; Giannini, L.; Coppedè, F.; Rossi, C.; Dardano, A.; Solini, A. Heterozygosity for the rs696217 SNP in the preproghrelin gene predicts weight loss after bariatric surgery in severely obese individuals. Obes. Surg. 2017, 27, 961–967. [Google Scholar] [CrossRef] [PubMed]
- Figueroa-Veja, N.; Jordán, B.; Pérez-Luque, E.L.; Parra-Laporte, L.; Garnelo, S.; Malacara, J.M. Effects of sleeve gastrectomy and rs9930506 FTO variants on angiopoietin/Tie-2 system in fat expansion and M1 macrophages recruitment in morbidly obese subjects. Endocrine 2016, 54, 700–713. [Google Scholar] [CrossRef] [PubMed]
- Krawczyk, M.; Jiménez-Agüero, R.; Alustiza, J.M.; Emparanza, J.I.; Perugorria, M.J.; Bujanda, L.; Lammert, F.; Banales, J.M. PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery. Surg. Obes. Relat. Dis. 2016, 12, 1838–1846. [Google Scholar] [CrossRef] [PubMed]
- Nicoletti, C.F.; Pinhel, M.A.; de Oliveira, B.A.; Marchini, J.S.; Salgado Junior, W.; Silva Junior, W.A.; Nonino, C.B. The genetic predisposition score of seven obesity-related single nucleotide polymorphisms is associated with better metabolic outcomes after Roux-en-Y gastric bypass. J. Nutrigenet. Nutrigenom. 2016, 9, 222–230. [Google Scholar] [CrossRef] [PubMed]
- Bandstein, M.; Mwinyi, J.; Ernst, B.; Thurnheer, M.; Schultes, B.; Schiöth, H.B. A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery. Scand. J. Gastroenterol. 2016, 51, 1050–1055. [Google Scholar] [CrossRef] [PubMed]
- Rodrigues, G.K.; Resende, C.M.; Durso, D.F.; Rodrigues, L.A.; Silva, J.L.; Reis, R.C.; Pereira, S.S.; Ferreira, D.C.; Franco, G.R.; Alvarez-Leite, J. A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery. Nutrition 2015, 31, 1344–1350. [Google Scholar] [CrossRef] [PubMed]
- Jia, P.; Her, C.; Chai, W. DNA excision repair at telomeres. DNA Repair 2015, 36, 137–145. [Google Scholar] [CrossRef] [PubMed]
- Blackburn, E.H. Telomeres and telomerase: The means to the end (Nobel lecture). Angew. Chem. Int. Ed. Eng. 2010, 49, 7405–7421. [Google Scholar] [CrossRef] [PubMed]
- Barceló, A.; Piérola, J.; López-Escribano, H.; de la Peña, M.; Soriano, J.B.; Alonso-Fernández, A.; Ladaria, A.; Agustí, A. Telomere shortening in sleep apnea syndrome. Respir. Med. 2010, 104, 1225–1229. [Google Scholar] [CrossRef] [PubMed]
- Lee, M.; Martin, H.; Firpo, M.A.; Demerath, E.W. Inverse association between adiposity and telomere length: The fels longitudinal study. Am. J. Hum. Biol. 2010, 23, 100–106. [Google Scholar] [CrossRef] [PubMed]
- Dersham, R.; Chu, X.; Wood, G.C.; Benotti, P.; Still, C.D.; Rolston, D.D. Changes in telomere length 3–5 years after gastric bypass surgery. Int. J. Obes. 2017. [Google Scholar] [CrossRef] [PubMed]
- Wong, J.M.; Collins, K. Telomere maintenance and disease. Lancet 2003, 362, 983–988. [Google Scholar] [CrossRef]
- Rode, L.; Nordestgaard, B.G.; Weischer, M.; Bojesen, S.E. Increased body mass index, elevated C-reactive protein, and short telomere length. J. Clin. Endocrinol. Metab. 2014, 99, E1671–E1675. [Google Scholar] [CrossRef] [PubMed]
- Harte, A.L.; da Silva, N.F.; Miller, M.A.; Cappuccio, F.P.; Kelly, A.; O’Hare, J.P.; Barnett, A.H.; Al-Daghri, N.M.; Al-Attas, O.; Alokail, M.; et al. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in south Asian males with type 2 dibates mellitus. Exp. Diabetes Res. 2012, 895185. [Google Scholar] [CrossRef] [PubMed]
- Salpea, K.D.; Humphries, S.E. Telomeres length in atherosclerosis and diabetes. Atherosclerosis 2010, 209, 35–38. [Google Scholar] [CrossRef] [PubMed]
- Cassidy, A.; De Vivo, I.; Liu, Y.; Han, J.; Prescott, J.; Hunter, D.J.; Rimm, E.B. Associations between diet, lifestyle factors, and telomere length in women. Am. J. Clin. Nutr. 2010, 91, 1273–1280. [Google Scholar] [CrossRef] [PubMed]
- O’Callaghan, N.J.; Clifton, P.M.; Noakes, M.; Fenech, M. Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res. 2009, 12, 169–176. [Google Scholar] [CrossRef] [PubMed]
- Formichi, C.; Cantara, S.; Ciuoli, C.; Neri, O.; Chiofalo, F.; Selmi, F.; Tirone, A.; Colasanto, G.; Di Cosmo, L.; Vuolo, G.; et al. Weight loss associated with bariatric surgery does not restore short telomere length of severe obese patients after 1 Year. Obes. Surg. 2014, 24, 2089–2093. [Google Scholar] [CrossRef] [PubMed]
- Epel, E.S. Psychological and metabolic stress: A recipe for accelerated cellular aging? Hormones 2009, 8, 7–22. [Google Scholar] [CrossRef] [PubMed]
- Laimer, M.; Melmer, A.; Lamina, C.; Raschenberger, J.; Adamovski, P.; Engl, J.; Ress, C.; Tschoner, A.; Gelsinger, C.; Mair, L.; et al. Telomere length increase after weight loss induced by bariatric surgery: Results from a 10 year prospective study. Int. J. Obes. 2016, 40, 773–778. [Google Scholar] [CrossRef] [PubMed]
- Carulli, L.; Anzivino, C.; Baldelli, E.; Zenobii, M.F.; Rocchi, M.B.; Bertolotti, M. Telomere length elongation after weight loss intervention in obese adults. Mol. Genet. Metab. 2016, 118, 138–142. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bernstein, B.E.; Meissner, A.; Lander, E.S. The mammalian epigenome. Cell 2007, 128, 669–681. [Google Scholar] [CrossRef] [PubMed]
- Fan, S.; Zhang, X. CpG island methylation pattern in different human tissues and its correlation with gene expression. Biochem. Biophys. Res. Commun. 2009, 383, 421–425. [Google Scholar] [CrossRef] [PubMed]
- Franks, P.W.; Ling, C. Epigenetics and obesity: The devil is in the details. BMC Med. 2010, 8, 88. [Google Scholar] [CrossRef] [PubMed]
- Udali, S.; Guarini, P.; Moruzzi, S.; Choi, S.W.; Friso, S. Cardiovascular epigenetics: From DNA methylation to microRNAs. Mol. Asp. Med. 2013, 34, 883–901. [Google Scholar] [CrossRef] [PubMed]
- Choi, S.W.; Friso, S. Epigenetics: A new bridge between nutrition and health. Adv. Nutr. 2010, 1, 8–16. [Google Scholar] [CrossRef] [PubMed]
- Saetrom, P.; Snove O., Jr.; Rossi, J.J. Epigenetics and microRNAs. Pediatr. Res. 2007, 61, 17R–23R. [Google Scholar] [CrossRef] [PubMed]
- Campión, J.; Milagro, F.; Martínez, J.A. Epigenetics and obesity. Prog. Mol. Biol. Transl. Sci. 2010, 94, 291–347. [Google Scholar] [CrossRef] [PubMed]
- Duthie, S.J. Epigenetic modifications and human pathologies: Cancer and CVD. Proc. Nutr. Soc. 2011, 70, 47–56. [Google Scholar] [CrossRef] [PubMed]
- Ramos-Lopez, O.; Milagro, F.I.; Allayee, H.; Chmurzynska, A.; Choi, M.S.; Curi, R.; De Caterina, R.; Ferguson, L.R.; Goni, L.; Kang, J.X.; et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J. Nutrigenet. Nutrigenom. 2017, 10, 43–62. [Google Scholar] [CrossRef] [PubMed]
- Boqué, N.; de la Iglesia, R.; de la Garza, A.L.; Milagro, F.I.; Olivares, M.; Bañuelos, O.; Soria, A.C.; Rodríguez-Sánchez, S.; Martínez, J.A.; Campión, J. Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns. Mol. Nutr. Food Res. 2013, 57, 1473–1478. [Google Scholar] [CrossRef] [PubMed]
- Uriarte, G.; Paternain, L.; Milagro, F.I.; Martínez, J.A.; Campion, J. Shifting to a control diet after a high-fat, highsucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats. J. Physiol. Biochem. 2013, 69, 601–611. [Google Scholar] [CrossRef] [PubMed]
- Milagro, F.I.; Campión, J.; Cordero, P.; Goyenechea, E.; Gómez-Uriz, A.M.; Abete, I.; Zulet, M.A.; Martínez, J.A. A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. FASEB J. 2011, 25, 1378–1389. [Google Scholar] [CrossRef] [PubMed]
- Cordero, P.; Campion, J.; Milagro, F.I.; Goyenechea, E.; Steemburgo, T.; Javierre, B.M.; Martinez, J.A. Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. J. Physiol. Biochem. 2011, 67, 463–470. [Google Scholar] [CrossRef] [PubMed]
- Crujeiras, A.B.; Campion, J.; Díaz-Lagares, A.; Milagro, F.I.; Goyenechea, E.; Abete, I.; Casanueva, F.F.; Martínez, J.A. Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: A translational study. Regul. Pept. 2013, 186, 1–6. [Google Scholar] [CrossRef] [PubMed]
- Nicoletti, C.F.; Nonino, C.B.; de Oliveira, B.A.; Pinhel, M.A.; Mansego, M.L.; Milagro, F.I.; Zulet, M.A.; Martinez, J.A. DNA methylation and hydroxymethylation levels in relation to two weight loss strategies: Energy-restricted diet or bariatric surgery. Obes. Surg. 2016, 26, 603–611. [Google Scholar] [CrossRef] [PubMed]
- Barres, R.; Kirchner, H.; Rasmussen, M.; Yan, J.; Kantor, F.R.; Krook, A.; Näslund, E.; Zierath, J.R. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013, 3, 1020–1027. [Google Scholar] [CrossRef] [PubMed]
- Falken, Y.; Hellstrom, P.M.; Holst, J.J.; Naslund, E. Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: Role of gut peptides. J. Clin. Endocrinol. Metab. 2011, 96, 2227–2235. [Google Scholar] [CrossRef] [PubMed]
- Rubino, F.; Forgione, A.; Cummings, D.E.; Vix, M.; Gnuli, D.; Mingrone, G.; Castagneto, M.; Marescaux, J. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann. Surg. 2006, 244, 741–749. [Google Scholar] [CrossRef] [PubMed]
- Kirchner, H.; Nylen, C.; Laber, S.; Barrès, R.; Yan, J.; Krook, A.; Zierath, J.R.; Näslund, E. Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass. Surg. Obes. Relat. Dis. 2014, 10, 671–678. [Google Scholar] [CrossRef] [PubMed]
- Morcillo, S.; Martín-Núñez, G.M.; García-Serrano, S.; Gutierrez-Repiso, C.; Rodriguez-Pacheco, F.; Valdes, S.; Gonzalo, M.; Rojo-Martinez, G.; Moreno-Ruiz, F.J.; Rodriguez-Cañete, A.; et al. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids. Sci. Rep. 2017, 7, 46292. [Google Scholar] [CrossRef] [PubMed]
- Nilsson, E.K.; Ernst, B.; Voisin, S.; Almén, M.S.; Benedict, C.; Mwinyi, J.; Fredriksson, R.; Schultes, B.; Schiöth, H.B. Rouxen-Y gastric bypass surgery induces genome-wide promoter-specific changes in DNA methylation in whole blood of obese patients. PLoS ONE 2015, 10, e0115186. [Google Scholar] [CrossRef] [PubMed]
- Ahrens, M.; Ammerpohl, O.; von Schönfels, W.; Kolarova, J.; Bens, S.; Itzel, T.; Teufel, A.; Herrmann, A.; Brosch, M.; Hinrichsen, H.; et al. DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab. 2013, 18, 296–302. [Google Scholar] [CrossRef] [PubMed]
- Benton, M.C.; Johnstone, A.; Eccles, D.; Harmon, B.; Hayes, M.T.; Lea, R.A.; Griffiths, L.; Hoffman, E.P.; Stubbs, R.S.; Macartney-Coxson, D. An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss. Genome Biol. 2015, 16, 8. [Google Scholar] [CrossRef] [PubMed]
- Martín-Núñez, G.M.; Cabrera-Mulero, A.; Alcaide-Torres, J.; García-Fuentes, E.; Tinahones, F.J.; Morcillo, S. No effect of different bariatric surgery procedures on LINE-1 DNA methylation in diabetic and nondiabetic morbidly obese patients. Surg. Obes. Relat. Dis. 2017, 13, 442–450. [Google Scholar] [CrossRef] [PubMed]
- Van Dijk, S.J.; Molloy, P.L.; Varinli, H.; Morrison, J.L.; Muhlhausler, B.S. Epigenetics and human obesity. Int. J. Obes. 2015, 39, 85–97. [Google Scholar] [CrossRef] [PubMed]
- Guénarda, F.; Deshaiesb, Y.; Cianfloneb, K.; Krald, J.G.; Marceauc, P.; Vohla, M.C. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc. Natl. Acad. Sci. USA 2013, 110, 11439–11444. [Google Scholar] [CrossRef] [PubMed]
- Donkin, I.; Versteyhe, S.; Ingerslev, L.R.; Qian, K.; Mechta, M.; Nordkap, L.; Mortensen, B.; Appel, E.V.; Jørgensen, N.; Kristiansen, V.B.; et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 2016, 23, 369–378. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Dedeurwaerder, S.; Defrance, M.; Calonne, E.; Denis, H.; Sotiriou, C.; Fuks, F. Evaluation of the infinium methylation 450K technology. Epigenomics 2011, 3, 771–784. [Google Scholar] [CrossRef] [PubMed]
- Ferguson, L.R. Nutrigenomics approaches to functional foods. J. Am. Diet. Assoc. 2009, 109, 452–458. [Google Scholar] [CrossRef] [PubMed]
- Mutch, D.M.; Temanni, M.R.; Henegar, C.; Combes, F.; Pelloux, V.; Holst, C.; Sørensen, T.I.; Astrup, A.; Martinez, J.A.; Saris, W.H.; et al. Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders. PLoS ONE 2007, 2, e1344. [Google Scholar] [CrossRef] [PubMed]
- Cortes-Oliveira, C.; Nicoletti, C.F.; Pinhel, M.A.S.; Oliveira, B.A.P.; Quinhoneiro, D.C.G.; Noronha, N.Y.; Marchini, J.S.; da Silva Júnior, W.A.; Júnior, W.S.; Nonino, C.B. UCP2 expression is associated with weight loss after hypocaloric diet intervention. Eur. J. Clin. Nutr. 2016, 1–5. [Google Scholar] [CrossRef] [PubMed]
- Cortes-Oliveira, C.; Nicoletti, C.F.; Pinhel, M.A.S.; Oliveira, B.A.P.; Quinhoneiro, D.C.G.; Noronha, N.Y.; Fassini, P.G.; Marchini, J.S.; da Silva Júnior, W.A.; Salgado Júnior, W.; et al. Influence of expression of UCP3, PLIN1 and PPARG2 on the oxidation of substrates after hypocaloric dietary intervention. Clin. Nutr. 2017, 1–6. [Google Scholar] [CrossRef]
- Ordovás, J.M.; Robertson, R.; Cléirigh, E.N. Gene–gene and gene–environment interactions defining lipid-related traits. Curr. Opin. Lipidol. 2011, 22, 129–136. [Google Scholar] [CrossRef] [PubMed]
- Pinhel, M.A.S.; Nicoletti, C.F.; Noronha, N.Y.; Oliveira, B.A.P.; Quinhoneiro, D.C.G.; Cortes-Oliveira, C.; Salgado, W., Jr.; Salgado Junior, W.; Machry, A.J.; da Silva Junior, W.A.; Souza, D.R.S.; et al. Changes in global transcriptional profiling of women following obesity surgery bypass. Obes. Surg. 2017. [Google Scholar] [CrossRef] [PubMed]
- Berisha, S.Z.; Serre, D.; Schauer, P.; Kashyap, S.R.; Smith, J.D. Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: A pilot study. PLoS ONE 2011, 6, e16729. [Google Scholar] [CrossRef] [PubMed]
- Ortega, F.J.; Vilallonga, R.; Xifra, G.; Sabater, M.; Ricart, W.; Fernández-Real, J.M. Bariatric surgery acutely changes the expression of inflammatory and lipogenic genes in obese adipose tissue. Surg. Obes. Relat. Dis. 2016, 12, 357–362. [Google Scholar] [CrossRef] [PubMed]
- Mardinoglu, A.; Heiker, J.T.; Gärtner, D.; Björnson, E.; Schön, M.R.; Flehmig, G.; Klöting, N.; Krohn, K.; Fasshauer, M.; Stumvoll, M.; et al. Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. Sci. Rep. 2015, 5, 14841. [Google Scholar] [CrossRef] [PubMed]
- Oliveira, B.A.P.; Pinhel, M.A.S.; Nicoletti, C.F.; Cortes-Oliveira, C.; Quinhoneiro, D.C.G.; Noronha, N.Y.; Fassini, P.G.; da Silva Júnior, W.A.; Junior, W.S.; Nonino, C.B. UCP2 and PLIN1 expression affects the resting metabolic rate and weight loss on obese patients. Obes. Surg. 2016, 27, 343–348. [Google Scholar] [CrossRef] [PubMed]
- Jürets, A.; Itariu, B.K.; Keindl, M.; Prager, G.; Langer, F.; Grablowitz, V.; Zeyda, M.; Stulnig, T.M. Upregulated TNF expression 1 year after bariatric surgery reflects a cachexia-like state in subcutaneous adipose tissue. Obes. Surg. 2017, 27, 1514–1523. [Google Scholar] [CrossRef] [PubMed]
- Leyvraz, C.; Verdumo, C.; Suter, M.; Paroz, A.; Calmes, J.M.; Marques-Vidal, P.M.; Giusti, V. Changes in gene expression profile in human subcutaneous adipose tissue during significant weight loss. Obes. Facts 2012, 5, 440–451. [Google Scholar] [CrossRef] [PubMed]
- Oliveira, B.A.P.; Pinhel, M.A.S.; Nicoletti, C.F.; Cortes-Oliveira, C.; Quinhoneiro, D.C.G.; Noronha, N.Y.; Marchini, J.S.; Marchry, A.J.; Junior, W.S.; Nonino, C.B. UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation and body composition. PLoS ONE 2016. [Google Scholar] [CrossRef] [PubMed]
- Hagman, D.K.; Larson, I.; Kuzma, J.N.; Cromer, G.; Makar, K.; Rubinow, K.B.; Foster-Schubert, K.E.; van Yserloo, B.; Billing, P.S.; Landerholm, R.W.; et al. The short-term and long-term effects of bariatric/metabolic surgery on subcutaneous adipose tissue inflammation in humans. Metabolism 2017, 70, 12–22. [Google Scholar] [CrossRef] [PubMed]
- Anhê, F.F.; Varin, T.V.; Schertzer, J.D.; Marette, A. The gut microbiota as a mediator of metabolic benefits after bariatric surgery. Can. J. Diabetes 2017, 30521–30524. [Google Scholar] [CrossRef] [PubMed]
- Tremaroli, V.; Karlsson, F.; Werling, M.; Ståhlman, M.; Kovatcheva-Datchary, P.; Olbers, T.; Fändriks, L.; le Roux, C.W.; Nielsen, J.; Bäckhed, F. Roux-en-Y gastric bypass and verticalbandedgastroplasty induce long-term changes on the human gutmicrobiome contributing to fat mass regulation. Cell Metab. 2015, 22, 228–238. [Google Scholar] [CrossRef] [PubMed]
- Liou, A.P.; Paziuk, M.; Luevano, J.M., Jr.; Machineni, S.; Turnbaugh, P.J.; Kaplan, L.M. Conserved shifts in the gut microbiotadue to gastric bypass reduce host weight and adiposity. Sci. Transl. Med. 2013, 5. [Google Scholar] [CrossRef] [PubMed]
- Qin, J.; Li, Y.; Cai, Z.; Li, S.; Zhu, J.; Zhang, F.; Liang, S.; Zhang, W.; Guan, Y.; Shen, D.; et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012, 490, 55–60. [Google Scholar] [CrossRef] [PubMed]
- Palleja, A.; Kashani, A.; Allin, K.H.; Nielsen, T.; Zhang, C.; Li, Y.; Brach, T.; Liang, S.; Feng, Q.; Jørgensen, N.B.; et al. Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota. Genome Med. 2016, 8, 67. [Google Scholar] [CrossRef] [PubMed]
- Zhang, H.; DiBaise, J.K.; Zuccolo, A.; Kudrna, D.; Braidotti, M.; Yu, Y.; Parameswarana, P.; Crowellb, M.D.; Wingc, R.; Rittmann, B.E.; et al. Human gutmicrobiota in obesity and after gastric bypass. Proc. Natl. Acad. Sci. USA 2009, 106, 2365–2370. [Google Scholar] [CrossRef] [PubMed]
- Graessler, J.; Qin, Y.; Zhong, H.; Zhang, J.; Licinio, J.; Wong, M.L.; Xu, A.; Chavakis, T.; Bornstein, A.B.; Ehrhart-Bornstein, M.; et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters. Pharmacogenom. J. 2013, 13, 514–522. [Google Scholar] [CrossRef] [PubMed]
- Kong, L.C.; Tap, J.; Aron-Wisnewsky, J.; Pelloux, V.; Basdevant, A.; Bouillot, J.L.; Zucker, J.D.; Doré, J.; Clément, K. Gut microbiota after gastric bypass in human obesity: Increased richness and associations of bacterial genera with adipose tissue genes. Am. J. Clin. Nutr. 2013, 98, 16–24. [Google Scholar] [CrossRef] [PubMed]
- Furet, J.P.; Kong, L.C.; Tap, J.; Poitou, C.; Basdevant, A.; Bouillot, J.L.; Mariat, D.; Corthier, G.; Doré, J.; Henegar, C.; et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: Links with metabolic and lowgrade inflammation markers. Diabetes 2010, 59, 3049–3057. [Google Scholar] [CrossRef] [PubMed]
Genes | Polymorphism | Main Results | Surgery/Time | N° Patients | Ref. |
---|---|---|---|---|---|
MC4R | rs17782313 | Women carrying this polymorphism present higher pre-surgical BMI and tend to maintain BMI > 35 kg/m2, which characterizes treatment failure | 60 months of RYGB | 217 | [21] |
UCP2 | Ala55Val −866G > A | Mutated alleles (T and A) could be biomarkers of weight loss | 12 months of RYGB | 150 | [22] |
FTO | rs9930506 | Weight percentage is significantly higher in carriers of the AG and GG genotypes | Six months of sleeve gastrectomy | 11 | [28] |
PNPLA3 TM6SF2 MBOAT7 | p.I148M p.E167E rs641738 | Mutated allele might be associated with greater improvement of hepatic steatosis after bariatric surgery | One year of gastric bypass gastric sleeve | 84 | [29] |
5-HT2C | rs3813929 | The TT genotype predicts greater percentage of excess weight loss among female patients | 12 months of RYGB | 351 | [24] |
FKBP5 | rs1360780 | The T allele is associated with weight loss. | Bariatric surgery | 42 | [25] |
UCP2 | Ala55Val −866G > A | Patients with at least one rare allele for polymorphisms and with at least one rare allele for both polymorphisms together (haplotype) present greater energy and carbohydrate intake even after adjustment for gender, age, and weight. | 12 months of RYGB | 150 | [30] |
32 SNPs | - | The LYPLAL1 genotype is associated with different eating behavior and loss of extensive body weight | Two years of RYGB | 251 | [31] |
330 SNPs | - | Information derived from patient DNA may be useful to predict surgical weight loss outcomes and to guide selection of surgical approach. | One year of RYGB or LAGB | 161 | [26] |
FTO | rs9939609 | Weight loss progresses differently in obese carriers of the FTO gene variant rs9939609 after bariatric surgery | Two months of RYGB | 146 | [32] |
Target Gene | Type of Material | Modification Type | Surgery/Time | Ref. |
---|---|---|---|---|
IL-6 | Whole blood | Decrease | six months after RYGB | [62] |
PDK4, IL-6, and TNF | Whole blood | Increase | 12 months after RYGB | [66] |
SCD-1 | Whole blood | Increase | six months after RYGB | [67] |
PGC-1a and PDK4 | Skeletal muscle | - | six months after RYGB | [63] |
ADK | - | Decrease | six months after RYGB | [68] |
PTPRE | Liver | Increase | - | [69] |
ETP, FOXP2, HDAC4 and DNMT3B | Adipose tissue | Decrease | - | [70] |
Global LINE-1 | Whole blood | Not modified | six months after RYGB | [71] |
Gene | Modification Type | Related Metabolic Pathways | Surgery/Time | Ref. |
---|---|---|---|---|
GGT1, CAMP, DEFA1, LCN2, TP53, PDSS1, OLR1, CNTNAP5, DHCR24, and HHAT | - | Lipid metabolism and obesity development | Six to twelve months after bariatric surgery (SG and RYGB) | [82] |
IL-6, IL-8, and TNF-alpha GLUT4, IRS1, and adiponectin | Increase Decrease | Inflammation Glucose metabolism | Acutely postoperative RYGB | [83] |
CIDEA Glutathione | Increase | Lipid droplet formation in the adipose tissue Glutathione metabolism | 12 months after bariatric surgery (SG and RYGB) | [84] |
UCP2 PLIN1 | Increase Unchanged | Thermogenesis Lipolysis | Six months after RYGB | [85] |
TNF, CASP3 | Increase | Inflammation | 12 months after bariatric surgery | [86] |
Leptin PPARg1 PPARg2 | Decrease Increase Unchanged | Insulin metabolism | 12 months after RYGB | [87] |
UCP1 UCP3 | Unchanged | Thermogenesis | Six months after RYGB | [88] |
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Nicoletti, C.F.; Cortes-Oliveira, C.; Pinhel, M.A.S.; Nonino, C.B. Bariatric Surgery and Precision Nutrition. Nutrients 2017, 9, 974. https://doi.org/10.3390/nu9090974
Nicoletti CF, Cortes-Oliveira C, Pinhel MAS, Nonino CB. Bariatric Surgery and Precision Nutrition. Nutrients. 2017; 9(9):974. https://doi.org/10.3390/nu9090974
Chicago/Turabian StyleNicoletti, Carolina F., Cristiana Cortes-Oliveira, Marcela A. S. Pinhel, and Carla B. Nonino. 2017. "Bariatric Surgery and Precision Nutrition" Nutrients 9, no. 9: 974. https://doi.org/10.3390/nu9090974