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Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels

Department of Sports Science, Japan Institute of Sports Science, Nishigaoka, Kitaku, Tokyo 115-0056, Japan
Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan
Author to whom correspondence should be addressed.
Nutrients 2017, 9(8), 820;
Received: 15 June 2017 / Revised: 21 July 2017 / Accepted: 28 July 2017 / Published: 30 July 2017
(This article belongs to the Special Issue Fe Deficiency, Dietary Bioavailbility and Absorption)
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Iron supplementation contributes an effort to improving iron status among athletes, but it does not always prevent iron deficiency. In the present study, we explored the effect of three consecutive days of endurance training (twice daily) on the hepcidin-25 (hepcidin) level. The effect of iron supplementation during this period was also determined. Fourteen male endurance athletes were enrolled and randomly assigned to either an iron-treated condition (Fe condition, n = 7) or a placebo condition (Control condition; CON, n = 7). They engaged in two 75-min sessions of treadmill running at 75% of maximal oxygen uptake on three consecutive days (days 1–3). The Fe condition took 12 mg of iron twice daily (24 mg/day), and the CON condition did not. On day 1, both conditions exhibited significant increases in serum hepcidin and plasma interleukin-6 levels after exercise (p < 0.05). In the CON condition, the hepcidin level did not change significantly throughout the training period. However, in the Fe condition, the serum hepcidin level on day 4 was significantly higher than that of the CON condition (p < 0.05). In conclusion, the hepcidin level was significantly elevated following three consecutive days of endurance training when moderate doses of iron were taken. View Full-Text
Keywords: iron related-hormone; endurance training; iron supplementation iron related-hormone; endurance training; iron supplementation

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Ishibashi, A.; Maeda, N.; Kamei, A.; Goto, K. Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels. Nutrients 2017, 9, 820.

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