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Nutrients 2017, 9(6), 625;

Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies

Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori—IRCCS–“Fondazione G. Pascale”, Via Mariano Semmola, 80131 Naples, Italy
S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori—IRCCS—“Fondazione G. Pascale”, 80131 Naples, Italy
Clinical, Experimental and Medical Sciences, Chair of Nephrology, Department of Cardio-Vascular Medicine, University of Study of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco, Via Marconi, 80059 Naples, Italy
These authors have contributed equally.
These authors are co-last authors.
Author to whom correspondence should be addressed.
Received: 12 May 2017 / Revised: 14 June 2017 / Accepted: 15 June 2017 / Published: 17 June 2017
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Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM: To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications. Design: Standard systematic review and narrative synthesis. Data Sources: MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study’s inclusion were: conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS/TQ compared to a placebo or other substance. All strains and genders were included. Results: The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review. Conclusions: Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals. View Full-Text
Keywords: Nigella sativa; Thymoquinone; natural compounds; chemotherapy-induced nephrotoxicity Nigella sativa; Thymoquinone; natural compounds; chemotherapy-induced nephrotoxicity

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Cascella, M.; Palma, G.; Barbieri, A.; Bimonte, S.; Amruthraj, N.J.; Muzio, M.R.; del Vecchio, V.; Rea, D.; Falco, M.; Luciano, A.; Arra, C.; Cuomo, A. Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies. Nutrients 2017, 9, 625.

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