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Nutrients 2017, 9(6), 622;

Dietary Management of Skin Health: The Role of Genistein

Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy
Department of Human Pathology, University of Messina, Messina 98125, Italy
Department of Biomedical Sciences, Dentistry and Morphological and Functional Images, University of Messina, Messina 98125, Italy
N.I. and G.P. equally contributed to this paper.
Author to whom correspondence should be addressed.
Received: 14 April 2017 / Revised: 13 June 2017 / Accepted: 14 June 2017 / Published: 17 June 2017
(This article belongs to the Special Issue Nutraceuticals and the Skin: Roles in Health and Disease)
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In women, aging and declining estrogen levels are associated with several cutaneous changes, many of which can be reversed or improved by estrogen supplementation. Two estrogen receptors—α and β—have been cloned and found in various tissue types. Epidermal thinning, declining dermal collagen content, diminished skin moisture, decreased laxity, and impaired wound healing have been reported in postmenopausal women. Experimental and clinical studies in postmenopausal conditions indicate that estrogen deprivation is associated with dryness, atrophy, fine wrinkling, and poor wound healing. The isoflavone genistein binds to estrogen receptor β and has been reported to improve skin changes. This review article will focus on the effects of genistein on skin health. View Full-Text
Keywords: genistein; skin; estrogen receptor beta genistein; skin; estrogen receptor beta

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Irrera, N.; Pizzino, G.; D’Anna, R.; Vaccaro, M.; Arcoraci, V.; Squadrito, F.; Altavilla, D.; Bitto, A. Dietary Management of Skin Health: The Role of Genistein. Nutrients 2017, 9, 622.

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