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Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial

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Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria
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Swiss Cardiovascular Center Bern, Department of Cardiology, Bern University Hospital, 3010 Bern, Switzerland
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Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria
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Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, 32545 Bad Oeynhausen, Germany
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Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
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Department of Internal Medicine, Division of Nephrology, Medical University of Graz, 8036 Graz, Austria
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Bad Gleichenberg Clinic, 8344 Bad Gleichenberg, Austria
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Medical Clinic V (Nephrology, Hypertensiology, Endocrinology), Medical Faculty Mannheim, Ruperto Carola University Heidelberg, 68167 Mannheim, Germany
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CBmed, Center for Biomarker Research in Medicine, 8010 Graz, Austria
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Author to whom correspondence should be addressed.
Nutrients 2017, 9(6), 623; https://doi.org/10.3390/nu9060623
Received: 27 April 2017 / Revised: 12 June 2017 / Accepted: 13 June 2017 / Published: 17 June 2017
Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial—a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect on IGF-1 (mean treatment effect 3.1; 95% confidence interval −5.6 to 11.9 ng/mL; p = 0.48), but it increased 1,25(OH)2D concentrations (mean treatment effect 9.2; 95% confidence interval 4.4 to 13.9 pg/mL; p ≤ 0.001). In this RCT, in hypertensive patients with low 25(OH)D concentrations, there was no significant effect of vitamin D supplementation on IGF-1 concentrations. However, we observed a cross-sectional correlation between 1,25(OH)2D and IGF-1 and an increase of 1,25(OH)2D after vitamin D supplementation. View Full-Text
Keywords: insulin-like growth factor-1; calcitriol; vitamin D supplementation insulin-like growth factor-1; calcitriol; vitamin D supplementation
MDPI and ACS Style

Trummer, C.; Schwetz, V.; Pandis, M.; Grübler, M.R.; Verheyen, N.; Gaksch, M.; Zittermann, A.; März, W.; Aberer, F.; Lang, A.; Friedl, C.; Tomaschitz, A.; Obermayer-Pietsch, B.; Pieber, T.R.; Pilz, S.; Treiber, G. Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. Nutrients 2017, 9, 623.

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