Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial
AbstractIncreasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)2D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial—a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)2D (r = 0.21; p = 0.005) but not with 25(OH)D (r = −0.008; p = 0.91). In the RCT, vitamin D had no significant effect on IGF-1 (mean treatment effect 3.1; 95% confidence interval −5.6 to 11.9 ng/mL; p = 0.48), but it increased 1,25(OH)2D concentrations (mean treatment effect 9.2; 95% confidence interval 4.4 to 13.9 pg/mL; p ≤ 0.001). In this RCT, in hypertensive patients with low 25(OH)D concentrations, there was no significant effect of vitamin D supplementation on IGF-1 concentrations. However, we observed a cross-sectional correlation between 1,25(OH)2D and IGF-1 and an increase of 1,25(OH)2D after vitamin D supplementation. View Full-Text
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Trummer, C.; Schwetz, V.; Pandis, M.; Grübler, M.R.; Verheyen, N.; Gaksch, M.; Zittermann, A.; März, W.; Aberer, F.; Lang, A.; Friedl, C.; Tomaschitz, A.; Obermayer-Pietsch, B.; Pieber, T.R.; Pilz, S.; Treiber, G. Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. Nutrients 2017, 9, 623.
Trummer C, Schwetz V, Pandis M, Grübler MR, Verheyen N, Gaksch M, Zittermann A, März W, Aberer F, Lang A, Friedl C, Tomaschitz A, Obermayer-Pietsch B, Pieber TR, Pilz S, Treiber G. Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. Nutrients. 2017; 9(6):623.Chicago/Turabian Style
Trummer, Christian; Schwetz, Verena; Pandis, Marlene; Grübler, Martin R.; Verheyen, Nicolas; Gaksch, Martin; Zittermann, Armin; März, Winfried; Aberer, Felix; Lang, Angelika; Friedl, Claudia; Tomaschitz, Andreas; Obermayer-Pietsch, Barbara; Pieber, Thomas R.; Pilz, Stefan; Treiber, Gerlies. 2017. "Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial." Nutrients 9, no. 6: 623.
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