Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)

Guo, Xiaohui; Tresserra-Rimbau, Anna; Estruch, Ramón; Martínez-González, Miguel A.; Medina-Remón, Alexander; Fitó, Montserrat; Corella, Dolores; Salas-Salvadó, Jordi; Portillo, Maria Puy; Moreno, Juan J.; Pi-Sunyer, Xavier; Lamuela-Raventós, Rosa M.

doi:10.3390/nu9050452

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

Printed Edition

A printed edition of this Special Issue is available at MDPI Books....

...

Open AccessArticle

Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)

Xiaohui Guo

¹,

Anna Tresserra-Rimbau

^1,2

Ramón Estruch

^2,3,

Miguel A. Martínez-González

^2,4,5

Alexander Medina-Remón

^2,3,

^2,6,

^2,7

^2,8

^2,9,

¹,

¹⁰ and

Rosa M. Lamuela-Raventós

^1,2,*

Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA-UB, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain

CIBEROBN Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain

Department of Internal Medicine, Hospital Clínic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain

⁴

Department of Preventive Medicine and Public Health, School of Medicine & IdiSNA (Institute for Health Research), University of Navarra, 31080 Pamplona, Spain

⁵

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA

⁶

Cardiovascular Risk and Nutrition Research Group (CARIN, Regicor Study Group), IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain

⁷

Department of Epidemiology, Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain

⁸

Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, IISPV, Rovira i Virgili University, 43201 Reus, Spain

⁹

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Institute, University of País Vasco (UPV/EHU), 01006 Vitoria, Spain

¹⁰

New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY 10032, USA

Author to whom correspondence should be addressed.

Nutrients 2017, 9(5), 452; https://doi.org/10.3390/nu9050452

Received: 17 March 2017 / Revised: 24 April 2017 / Accepted: 26 April 2017 / Published: 3 May 2017

(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Overweight and obesity have been steadily increasing in recent years and currently represent a serious threat to public health. Few human studies have investigated the relationship between polyphenol intake and body weight. Our aim was to assess the relationship between urinary polyphenol levels and body weight. A cross-sectional study was performed with 573 participants from the PREDIMED (Prevención con Dieta Mediterránea) trial (ISRCTN35739639). Total polyphenol levels were measured by a reliable biomarker, total urinary polyphenol excretion (TPE), determined by the Folin-Ciocalteu method in urine samples. Participants were categorized into five groups according to their TPE at the fifth year. Multiple linear regression models were used to assess the relationships between TPE and obesity parameters; body weight (BW), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). After a five years follow up, significant inverse correlations were observed between TPE at the 5th year and BW (β = −1.004; 95% CI: −1.634 to −0.375, p = 0.002), BMI (β = −0.320; 95% CI: −0.541 to −0.098, p = 0.005), WC (β = −0.742; 95% CI: −1.326 to −0.158, p = 0.013), and WHtR (β = −0.408; 95% CI: −0.788 to −0.028, p = 0.036) after adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute to reducing body weight in elderly people at high cardiovascular risk. View Full-Text

Keywords: overweight; obesity; polyphenol; urine; PREDIMED

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
ZIP-Document (ZIP, 858 KiB)

Share and Cite

MDPI and ACS Style

Guo, X.; Tresserra-Rimbau, A.; Estruch, R.; Martínez-González, M.A.; Medina-Remón, A.; Fitó, M.; Corella, D.; Salas-Salvadó, J.; Portillo, M.P.; Moreno, J.J.; Pi-Sunyer, X.; Lamuela-Raventós, R.M. Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study). Nutrients 2017, 9, 452. https://doi.org/10.3390/nu9050452

AMA Style

Guo X, Tresserra-Rimbau A, Estruch R, Martínez-González MA, Medina-Remón A, Fitó M, Corella D, Salas-Salvadó J, Portillo MP, Moreno JJ, Pi-Sunyer X, Lamuela-Raventós RM. Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study). Nutrients. 2017; 9(5):452. https://doi.org/10.3390/nu9050452

Chicago/Turabian Style

Guo, Xiaohui, Anna Tresserra-Rimbau, Ramón Estruch, Miguel A. Martínez-González, Alexander Medina-Remón, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Maria P. Portillo, Juan J. Moreno, Xavier Pi-Sunyer, and Rosa M. Lamuela-Raventós. 2017. "Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)" Nutrients 9, no. 5: 452. https://doi.org/10.3390/nu9050452

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Printed Edition

Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI