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Open AccessArticle

Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention

1
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
2
Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON N1G 2W1, Canada
3
Department of Mathematics and Statistics, University of Guelph, Guelph, ON N1G 2W1, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(3), 240; https://doi.org/10.3390/nu9030240
Received: 25 January 2017 / Revised: 27 February 2017 / Accepted: 3 March 2017 / Published: 6 March 2017
(This article belongs to the Special Issue Nutrigenetics)
Nutrigenetics research is anticipated to lay the foundation for personalized dietary recommendations; however, it remains unclear if providing individuals with their personal genetic information changes dietary behaviors. Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 (FADS1) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18–25 years). Participants were randomized into Genetic (intervention) and Non-Genetic (control) groups, with measurements taken at Baseline and Final (12 weeks). Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was assessed using an omega-3 food frequency questionnaire. Red blood cell (RBC) FA content was quantified by gas chromatography. Implications of participation in a nutrigenetics study and awareness of omega-3 FAs were assessed with online questionnaires. Upon completion of the study, EPA and DHA intake increased significantly (p = 1.0 × 10−4) in all participants. This change was reflected by small increases in RBC %EPA. Participants in the Genetic group showed increased awareness of omega-3 terminology by the end of the study, reported that the dietary recommendations were more useful, and rated cost as a barrier to omega-3 consumption less often than those in the Non-Genetic group. Providing participants FADS1 genetic information did not appear to influence omega-3 intake during the 12 weeks, but did change perceptions and behaviors related to omega-3 FAs in this timeframe. View Full-Text
Keywords: omega-3 fats; nutrigenomics; personalized nutrition; eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; single nucleotide polymorphisms; SNPs; fatty acid desaturase 1 omega-3 fats; nutrigenomics; personalized nutrition; eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; single nucleotide polymorphisms; SNPs; fatty acid desaturase 1
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MDPI and ACS Style

Roke, K.; Walton, K.; Klingel, S.L.; Harnett, A.; Subedi, S.; Haines, J.; Mutch, D.M. Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention. Nutrients 2017, 9, 240. https://doi.org/10.3390/nu9030240

AMA Style

Roke K, Walton K, Klingel SL, Harnett A, Subedi S, Haines J, Mutch DM. Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention. Nutrients. 2017; 9(3):240. https://doi.org/10.3390/nu9030240

Chicago/Turabian Style

Roke, Kaitlin; Walton, Kathryn; Klingel, Shannon L.; Harnett, Amber; Subedi, Sanjeena; Haines, Jess; Mutch, David M. 2017. "Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention" Nutrients 9, no. 3: 240. https://doi.org/10.3390/nu9030240

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