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Nutrients
Volume 9
Issue 2
10.3390/nu9020165
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Article

Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells

by
Hee Soon Shin
1,2,3,
Hideo Satsu
1,4,*,
Min-Jung Bae
1,5,
Mamoru Totsuka
1 and
Makoto Shimizu
1,6
1
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
2
Division of Nutrition and Metabolism Research, Korea Food Research Institute, Seongnam-si 13539, Korea
3
Department of Food Biotechnology, University of Science and Technology (UST), Daejeon 34113, Korea
4
Department of Biotechnology, Faculty of Engineering, Maebashi Institute of Technology, Gunma 371-0816, Japan
5
Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Korea
6
Department of Nutritional Science, Tokyo University of Agriculture, Tokyo 156-8502, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(2), 165; https://doi.org/10.3390/nu9020165
Received: 30 December 2016 / Revised: 5 February 2017 / Accepted: 13 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue Nutrition and Diet in IBD)
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Abstract

Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases. Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity. They also significantly suppressed nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcriptional activity, nuclear translocation of the p65 subunit, and phosphorylation of IκB kinase (IKK). Additionally, upstream of IKK, protein kinase D (PKD) was also suppressed. Finally, we found that they scavenged H2O2-induced reactive oxygen species (ROS) and the functional moiety responsible for the anti-inflammatory effects of CHA and CA was the catechol group. Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-κB signaling in human intestinal epithelial cells. View Full-Text
Keywords: chlorogenic acid; caffeic acid; interleukine-8; nuclear factor κB; protein kinase D; reactive oxygen species; catechol group chlorogenic acid; caffeic acid; interleukine-8; nuclear factor κB; protein kinase D; reactive oxygen species; catechol group
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MDPI and ACS Style

Shin, H.S.; Satsu, H.; Bae, M.-J.; Totsuka, M.; Shimizu, M. Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells. Nutrients 2017, 9, 165. https://doi.org/10.3390/nu9020165

AMA Style

Shin HS, Satsu H, Bae M-J, Totsuka M, Shimizu M. Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells. Nutrients. 2017; 9(2):165. https://doi.org/10.3390/nu9020165

Chicago/Turabian Style

Shin, Hee S., Hideo Satsu, Min-Jung Bae, Mamoru Totsuka, and Makoto Shimizu. 2017. "Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells" Nutrients 9, no. 2: 165. https://doi.org/10.3390/nu9020165

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