Next Article in Journal
Image-Based Dietary Assessment Ability of Dietetics Students and Interns
Next Article in Special Issue
Diabetes Mellitus and Younger Age Are Risk Factors for Hyperphosphatemia in Peritoneal Dialysis Patients
Previous Article in Journal
Is the Proportion of Carbohydrate Intake Associated with the Incidence of Diabetes Complications?—An Analysis of the Japan Diabetes Complications Study
Previous Article in Special Issue
Very Low-Protein Diet (VLPD) Reduces Metabolic Acidosis in Subjects with Chronic Kidney Disease: The “Nutritional Light Signal” of the Renal Acid Load
Open AccessReview

Effects of Magnesium on the Phosphate Toxicity in Chronic Kidney Disease: Time for Intervention Studies

1
Department of Comprehensive Kidney Disease Research, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita 565-0871, Japan
2
Department of Nephrology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita 565-0871, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(2), 112; https://doi.org/10.3390/nu9020112
Received: 11 December 2016 / Revised: 20 January 2017 / Accepted: 3 February 2017 / Published: 6 February 2017
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease)
Magnesium, an essential mineral for human health, plays a pivotal role in the cardiovascular system. Epidemiological studies in the general population have found an association between lower dietary magnesium intake and an elevated risk of cardiovascular events. In addition, magnesium supplementation was shown to improve blood pressure control, insulin sensitivity, and endothelial function. The relationship between magnesium and cardiovascular prognosis among patients with chronic kidney disease (CKD) has been increasingly investigated as it is becoming evident that magnesium can inhibit vascular calcification, a prominent risk of cardiovascular events, which commonly occurs in CKD patients. Cohort studies in patients receiving dialysis have shown a lower serum magnesium level as a significant risk for cardiovascular mortality. Interestingly, the cardiovascular mortality risk associated with hyperphosphatemia is alleviated among those with high serum magnesium levels, consistent with in vitro evidence that magnesium inhibits high-phosphate induced calcification of vascular smooth muscle cells. Furthermore, a harmful effect of high phosphate on the progression of CKD is also attenuated among those with high serum magnesium levels. The potential usefulness of magnesium as a remedy for phosphate toxicity should be further explored by future intervention studies. View Full-Text
Keywords: magnesium; chronic kidney disease; dialysis; cardiovascular disease; phosphate toxicity; vascular calcification magnesium; chronic kidney disease; dialysis; cardiovascular disease; phosphate toxicity; vascular calcification
Show Figures

Figure 1

MDPI and ACS Style

Sakaguchi, Y.; Hamano, T.; Isaka, Y. Effects of Magnesium on the Phosphate Toxicity in Chronic Kidney Disease: Time for Intervention Studies. Nutrients 2017, 9, 112.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop