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Nutritional Therapy in Liver Transplantation
Open AccessReview

Nutritional Needs and Support for Children with Chronic Liver Disease

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Lucile Packard Children’s Hospital, Palo Alto, Stanford, CA 94304, USA
Department of Medicine, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA
Author to whom correspondence should be addressed.
Nutrients 2017, 9(10), 1127;
Received: 22 August 2017 / Revised: 8 October 2017 / Accepted: 11 October 2017 / Published: 16 October 2017
(This article belongs to the Special Issue Nutrition and Liver Disease)
Malnutrition has become a dangerously common problem in children with chronic liver disease, negatively impacting neurocognitive development and growth. Furthermore, many children with chronic liver disease will eventually require liver transplantation. Thus, this association between malnourishment and chronic liver disease in children becomes increasingly alarming as malnutrition is a predictor of poorer outcomes in liver transplantation and is often associated with increased morbidity and mortality. Malnutrition requires aggressive and appropriate management to correct nutritional deficiencies. A comprehensive review of the literature has found that infants with chronic liver disease (CLD) are particularly susceptible to malnutrition given their low reserves. Children with CLD would benefit from early intervention by a multi-disciplinary team, to try to achieve nutritional rehabilitation as well as to optimize outcomes for liver transplant. This review explains the multifactorial nature of malnutrition in children with chronic liver disease, defines the nutritional needs of these children, and discusses ways to optimize their nutritional. View Full-Text
Keywords: nutrition; chronic liver disease; children nutrition; chronic liver disease; children
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Yang, C.H.; Perumpail, B.J.; Yoo, E.R.; Ahmed, A.; Kerner Jr., J.A. Nutritional Needs and Support for Children with Chronic Liver Disease. Nutrients 2017, 9, 1127.

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