Next Article in Journal
The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults
Next Article in Special Issue
Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study
Previous Article in Journal
Physical Activity and Beverage Consumption among Adolescents
Previous Article in Special Issue
Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models
Open AccessArticle

Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

by 1,†, 2,†, 1, 1 and 1,*
1
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China
2
Phase I Clinical Research Unit, West China Hospital, Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(7), 388; https://doi.org/10.3390/nu8070388
Received: 17 April 2016 / Revised: 9 June 2016 / Accepted: 16 June 2016 / Published: 23 June 2016
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
The aim of this study was to evaluate evidence for the efficacy of aloe vera on managing prediabetes and early non-treated diabetes mellitus. We performed a systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials until 28 January 2016. A total of five randomized controlled trials (RCTs) involving 415 participants were included. Compared with the controls, aloe vera supplementation significantly reduced the concentrations of fasting blood glucose (FBG) (p = 0.02; weighed mean difference [WMD]: −30.05 mg/dL; 95% confidence interval [CI]: −54.87 to −5.23 mg/dL), glycosylated hemoglobin A1c (HbA1c) (p < 0.00001; WMD: −0.41%; 95% CI: −0.55% to −0.27%), triglyceride (p = 0.0001), total cholesterol (TC) (p < 0.00001), and low density lipoprotein-cholesterol (LDL-C) (p < 0.00001). Aloe vera was superior to placebo in increasing serum high density lipoprotein-cholesterol (HDL-C) levels (p = 0.04). Only one adverse event was reported. The evidence from RCTs showed that aloe vera might effectively reduce the levels of FBG, HbA1c, triglyceride, TC and LDL-C, and increase the levels of HDL-C on prediabetes and early non-treated diabetic patients. Limited evidence exists about the safety of aloe vera. Given the small number and poor quality of RCTs included in the meta-analysis, these results are inconclusive. A large-scale, well-designed RCT is needed to further address this issue. View Full-Text
Keywords: aloe vera; prediabetes; randomized controlled trials; meta-analysis aloe vera; prediabetes; randomized controlled trials; meta-analysis
Show Figures

Figure 1

MDPI and ACS Style

Zhang, Y.; Liu, W.; Liu, D.; Zhao, T.; Tian, H. Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2016, 8, 388. https://doi.org/10.3390/nu8070388

AMA Style

Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016; 8(7):388. https://doi.org/10.3390/nu8070388

Chicago/Turabian Style

Zhang, Yiyi; Liu, Wen; Liu, Dan; Zhao, Tieyun; Tian, Haoming. 2016. "Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Nutrients 8, no. 7: 388. https://doi.org/10.3390/nu8070388

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop