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Open AccessArticle

The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults

School of Public Health, Capital Medical University, Beijing 100069, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(7), 385;
Received: 27 April 2016 / Revised: 24 May 2016 / Accepted: 17 June 2016 / Published: 23 June 2016
Objective: To explore the relationship between the erythrocyte fatty acid profile and cognition in elderly Chinese adults. Methods: 60 mild cognitive impairment (MCI) subjects and 60 age- and gender-matched control adults (aged 55 years and above) were involved in this cross-sectional study. Cognitive function was measured by using the Montreal Cognitive Assessment (MoCA) test. Information regarding the demographic characteristics and lifestyle of the participants was collected with a questionnaire. A semi-quantified food frequency questionnaire (FFQ) method was used for dietary assessment. The erythrocytes fatty acid profile was measured. Results: The MCI subjects had a lower education level than the control subjects (p < 0.05). Compared with control subjects, MCI subjects had higher daily poultry intake and lower fish intake (p < 0.05). Erythrocyte fatty acid profile of the MCI subjects was characterized as lower erythrocyte proportions of 20:4 n-6, 20:5 n-3, and total n-3 fatty acids compared with control subjects (p < 0.05). An association of erythrocyte proportions of 18:0, 22:0, total SFA, 18:2 n-6, 24:4 n-6 fatty acids, docosahexaenoic acid (DHA), and total n-6 PUFAs with cognition in elderly Chinese adults was detected. Conclusion: The erythrocyte fatty acid profile was related to cognitionin the elderly. Lower erythrocyte unsaturated fatty acid and higher saturated fatty acid proportions might predict cognitive function decline in elderly Chinese adults. View Full-Text
Keywords: erythrocyte fatty acids; lipids; cognition; the elderly erythrocyte fatty acids; lipids; cognition; the elderly
MDPI and ACS Style

Yuan, L.; Zhen, J.; Ma, W.; Cai, C.; Huang, X.; Xiao, R. The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults. Nutrients 2016, 8, 385.

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