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Resveratrol and Ophthalmic Diseases

Department of Ophthalmology, University of Florida College of Medicine, FL 32209, USA
Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11424, Saudi Arabia
Author to whom correspondence should be addressed.
Nutrients 2016, 8(4), 200;
Received: 25 February 2016 / Revised: 25 March 2016 / Accepted: 29 March 2016 / Published: 5 April 2016
Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness. In vitro and in vivo (animal model) experimental studies performed so far have provided evidence for the biological effects of resveratrol on numerous pathways including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, pro-survival or angiogenesis that are implicated in the pathogenesis of these age-related ocular disorders. In this review, we provide a brief overview of current scientific literature on resveratrol, its plausible mechanism(s) of action, its potential use and current limitations as a nutritional therapeutic intervention in the eye and its related disorders. View Full-Text
Keywords: age-related macular degeneration; cataract; diabetic retinopathy; eye; glaucoma; ocular disease; phytochemicals age-related macular degeneration; cataract; diabetic retinopathy; eye; glaucoma; ocular disease; phytochemicals
MDPI and ACS Style

Abu-Amero, K.K.; Kondkar, A.A.; Chalam, K.V. Resveratrol and Ophthalmic Diseases. Nutrients 2016, 8, 200.

AMA Style

Abu-Amero KK, Kondkar AA, Chalam KV. Resveratrol and Ophthalmic Diseases. Nutrients. 2016; 8(4):200.

Chicago/Turabian Style

Abu-Amero, Khaled K., Altaf A. Kondkar, and Kakarla V. Chalam 2016. "Resveratrol and Ophthalmic Diseases" Nutrients 8, no. 4: 200.

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