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The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility
Open AccessArticle

A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes

Obstetrics and Gynecology Unit, San Raffaele Scientific Institute, 20132 Milano, Italy
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy
Author to whom correspondence should be addressed.
Nutrients 2016, 8(3), 109;
Received: 30 November 2015 / Revised: 5 February 2016 / Accepted: 18 February 2016 / Published: 23 February 2016
(This article belongs to the Special Issue Premenopausal Nutrition and Fertility)
The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the environmental milieu within the uterus. With the aim to better understand the mechanisms underlying the potential deleterious effect of an increased BMI on IVF outcomes, we have evaluated the effects of female BMI on number and quality of retrieved oocytes, fertilization rate, embryo score and incidences of ongoing pregnancy and live births among couples undergoing IVF in an Italian population. Data from 1602 women who underwent their first IVF cycle were retrospectively analyzed. A significantly reduced percentage of mature oocytes when comparing obese (BMI ≥ 30 kg/m2) and normal-weight patients (BMI = 18.50–24.99 kg/m2) was found. After adjusting for maternal age and other confounders, odds for ongoing pregnancy rate showed no differences across different BMI categories. However, a significant increased odds ratio (OR) could be observed for miscarriage rate in patients with BMI ≥ 25 (OR = 2.5; p = 0.04). These results should be taken into account in order to define optimal strategies for overweight and obese patients referring to ART procedures. View Full-Text
Keywords: BMI; assisted reproduction; infertility; oocyte BMI; assisted reproduction; infertility; oocyte
MDPI and ACS Style

Sarais, V.; Pagliardini, L.; Rebonato, G.; Papaleo, E.; Candiani, M.; Viganò, P. A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes. Nutrients 2016, 8, 109.

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