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Polyphenols and DNA Damage: A Mixed Blessing

by 1,2,* and 3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, C/Irunlarrea 1, 31009 Pamplona, Spain
IdiSNA, Navarra Institute for Health Research
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PB 1046 Blindern, 0316 Oslo, Norway
Author to whom correspondence should be addressed.
Nutrients 2016, 8(12), 785;
Received: 11 October 2016 / Revised: 15 November 2016 / Accepted: 23 November 2016 / Published: 3 December 2016
(This article belongs to the Special Issue Polyphenols for Cancer Treatment or Prevention)
Polyphenols are a very broad group of chemicals, widely distributed in plant foods, and endowed with antioxidant activity by virtue of their numerous phenol groups. They are widely studied as putative cancer-protective agents, potentially contributing to the cancer preventive properties of fruits and vegetables. We review recent publications relating to human trials, animal experiments and cell culture, grouping them according to whether polyphenols are investigated in whole foods and drinks, in plant extracts, or as individual compounds. A variety of assays are in use to study genetic damage endpoints. Human trials, of which there are rather few, tend to show decreases in endogenous DNA damage and protection against DNA damage induced ex vivo in blood cells. Most animal experiments have investigated the effects of polyphenols (often at high doses) in combination with known DNA-damaging agents, and generally they show protection. High concentrations can themselves induce DNA damage, as demonstrated in numerous cell culture experiments; low concentrations, on the other hand, tend to decrease DNA damage. View Full-Text
Keywords: polyphenols; flavonoids; human studies; in vitro; in vivo; DNA damage; DNA protection polyphenols; flavonoids; human studies; in vitro; in vivo; DNA damage; DNA protection
MDPI and ACS Style

Azqueta, A.; Collins, A. Polyphenols and DNA Damage: A Mixed Blessing. Nutrients 2016, 8, 785.

AMA Style

Azqueta A, Collins A. Polyphenols and DNA Damage: A Mixed Blessing. Nutrients. 2016; 8(12):785.

Chicago/Turabian Style

Azqueta, Amaya, and Andrew Collins. 2016. "Polyphenols and DNA Damage: A Mixed Blessing" Nutrients 8, no. 12: 785.

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