Unraveling the Anticancer Effect of Curcumin and Resveratrol
by
Aline Renata Pavan †, Gabriel Dalio Bernardes da Silva †
, Daniela Hartmann Jornada †, Diego Eidy Chiba †, Guilherme Felipe dos Santos Fernandes †, Chung Man Chin † and Jean Leandro Dos Santos *,†
Aline Renata Pavan †, Gabriel Dalio Bernardes da Silva †, Daniela Hartmann Jornada †, Diego Eidy Chiba †, Guilherme Felipe dos Santos Fernandes †, Chung Man Chin † and Jean Leandro Dos Santos *,†
School of Pharmaceutical Sciences, UNESP–Univ Estadual Paulista, Araraquara 14800903, Brazil
*
Author to whom correspondence should be addressed.
†
All authors contributed equally to this work.
Nutrients 2016, 8(11), 628; https://doi.org/10.3390/nu8110628
Received: 4 September 2016 / Revised: 24 September 2016 / Accepted: 27 September 2016 / Published: 10 November 2016
(This article belongs to the Special Issue Polyphenols for Cancer Treatment or Prevention)
Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.
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Keywords:
cancer; resveratrol; curcumin; polyphenols; anticancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Pavan, A.R.; Silva, G.D.B.; Jornada, D.H.; Chiba, D.E.; Fernandes, G.F.S.; Man Chin, C.; Dos Santos, J.L. Unraveling the Anticancer Effect of Curcumin and Resveratrol. Nutrients 2016, 8, 628.
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