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Open AccessArticle

High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease

Division of Nephrology, Department of medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China
Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(10), 645;
Received: 14 August 2016 / Revised: 27 September 2016 / Accepted: 3 October 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease)
Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to our hospital. Patients were divided into two groups: hyperhomocysteinemia and normohomocysteinemia. Multivariable linear regression analyses were used to evaluate the association between plasma homocysteine and renal/cardiovascular parameters. The prevalence of HHcy in patients with CKD was 52.78%, and the prevalence in CKD stage 1, stage 2, stage 3, stage 4 and stage 5 patients was 10.73%, 29.22%, 58.71%, 75.23% and 83.75%, respectively. Patients with HHcy had higher incidences of renal damage, left ventricular hypertrophy, left ventricular diastolic dysfunction and abnormal carotid intima-media thickness compared with patients with normohomocysteinemia (p < 0.05), while multivariable linear regression analyses showed plasma homocysteine was only associated with the estimated glomerular filtration rate (eGFR). eGFR, uric acid, albumin, gender, hemoglobin and calcium×phosphate were associated with levels of plasma homocysteine in these CKD patients. The prevalence of HHcy in Chinese patients with CKD was high, and serum homocysteine levels were associated with impaired renal function in these patients. View Full-Text
Keywords: chronic kidney disease; hyperhomocysteinemia chronic kidney disease; hyperhomocysteinemia
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Ye, Z.; Zhang, Q.; Li, Y.; Wang, C.; Zhang, J.; Ma, X.; Peng, H.; Lou, T. High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease. Nutrients 2016, 8, 645.

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