Next Article in Journal
Nutrient Intake Is Insufficient among Senegalese Urban School Children and Adolescents: Results from Two 24 h Recalls in State Primary Schools in Dakar
Previous Article in Journal
High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease
Article Menu

Export Article

Open AccessArticle

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
Graduate Institute of Health Industry Technology, Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
Department of Orthopedic Surgery, Taipei Medical University Shuang Ho Hospital, New Taipei City 23561, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(10), 648;
Received: 23 August 2016 / Revised: 8 October 2016 / Accepted: 13 October 2016 / Published: 20 October 2016
PDF [2730 KB, uploaded 20 October 2016]


Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge. Female Institute of Cancer Research (ICR) mice from four groups (n = 8 per group) were orally administered CAP for 4 weeks at 0, 205, 410, and 1025 mg/kg/day, which were respectively designated the vehicle, CAP-1X, CAP-2X, and CAP-5X groups. The anti-fatigue activity and exercise performance was evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, BUN (blood urea nitrogen) and creatine kinase (CK) after a 15-min swimming exercise. The grip strength and exhaustive swimming time of the CAP-5X group were significantly higher than other groups. CAP supplementation dose-dependently reduced serum lactate, ammonia, BUN and CK levels, and increased glucose concentration after the 15-min swimming test. In addition, CAP also increased hepatic glycogen content, an important energy source for exercise. The possible mechanism was relevant to energy homeostasis and the physiological modulations by CAP supplementation. Therefore, our results suggest that CAP supplementation may have a wide spectrum of bioactivities for promoting health, performance improvement and fatigue amelioration. View Full-Text
Keywords: capsaicin; anti-fatigue; exercise performance; forelimb grip strength; glycogen capsaicin; anti-fatigue; exercise performance; forelimb grip strength; glycogen

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hsu, Y.-J.; Huang, W.-C.; Chiu, C.-C.; Liu, Y.-L.; Chiu, W.-C.; Chiu, C.-H.; Chiu, Y.-S.; Huang, C.-C. Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice. Nutrients 2016, 8, 648.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top