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Review

Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials

by 1,†, 1,†, 1, 1, 1 and 2,3,*
1
School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China
2
College of Food Science, Southwest University, Chongqing 400716, China
3
Chongqing Engineering Research Centre of Regional Foods, Chongqing 400716, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(1), 39; https://doi.org/10.3390/nu8010039
Received: 17 October 2015 / Revised: 9 December 2015 / Accepted: 7 January 2016 / Published: 13 January 2016
(This article belongs to the Special Issue Cereal Grains for Human Health)
Many individual studies on oat β-glucan (OBG) confirmed its functionality in improving type 2 diabetes mellitus (T2DM), but disagreements were identified among those results. To derive a pooled estimate of these results, relevant articles, published before 5 September 2015, were collected from four electronic databases (Pubmed, Cochrane Library, Scopus, and Web of Science) and subjected to meta-analysis in the present work. In total, four articles, dealing with 350 T2DM patients combined, met the inclusion criteria. Compared to control, T2DM patients administrated OBG from 2.5 to 3.5 g/day for 3 to 8 weeks presented significantly lowered concentrations in fasting plasma glucose (FPG) by −0.52 (95% CI: −0.94, −0.10) mmol/L (p = 0.01) and glycosylated hemoglobin (HbA1c) by −0.21% (95% CI: −0.40, −0.02) (p = 0.03). However, OBG intake did not significantly lower the fasting plasma insulin (FPI) concentration. In conclusion, mediate-term OBG intake (3–8 weeks) favored the glycaemic control of T2DM patients but did not improve their insulin sensitivity. Regrettably, data upon the effects of long-term OBG intake on glycaemic control and insulin sensitivity were scarce, which is of much importance and should be addressed in future research. View Full-Text
Keywords: oat β-glucan; diabetes mellitus; glycaemic control; insulin sensitivity; meta-analysis oat β-glucan; diabetes mellitus; glycaemic control; insulin sensitivity; meta-analysis
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MDPI and ACS Style

Shen, X.L.; Zhao, T.; Zhou, Y.; Shi, X.; Zou, Y.; Zhao, G. Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2016, 8, 39. https://doi.org/10.3390/nu8010039

AMA Style

Shen XL, Zhao T, Zhou Y, Shi X, Zou Y, Zhao G. Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016; 8(1):39. https://doi.org/10.3390/nu8010039

Chicago/Turabian Style

Shen, Xiao Li, Tao Zhao, Yuanzhong Zhou, Xiuquan Shi, Yan Zou, and Guohua Zhao. 2016. "Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials" Nutrients 8, no. 1: 39. https://doi.org/10.3390/nu8010039

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