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GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition

Department of General Surgery, Jinling Hospital Affiliated to Southern Medical University, Nanjing 210002, China
Research Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(1), 33;
Received: 7 December 2015 / Revised: 3 January 2016 / Accepted: 5 January 2016 / Published: 9 January 2016
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We investigated the effects of exogenous glucagon-like peptide-2 (GLP-2) on mucosal atrophy and intestinal antioxidant capacity in a mouse model of total parenteral nutrition (TPN). Male mice (6–8 weeks old) were divided into three groups (n = 8 for each group): a control group fed a standard laboratory chow diet, and experimental TPN (received standard TPN solution) and TPN + GLP-2 groups (received TPN supplemented with 60 µg/day of GLP-2 for 5 days). Mice in the TPN group had lower body weight and reduced intestinal length, villus height, and crypt depth compared to the control group (all p < 0.05). GLP-2 supplementation increased all parameters compared to TPN only (all p < 0.05). Intestinal total superoxide dismutase activity and reduced-glutathione level in the TPN + GLP-2 group were also higher relative to the TPN group (all p < 0.05). GLP-2 administration significantly upregulated proliferating cell nuclear antigen expression and increased glucose-regulated protein (GRP78) abundance. Compared with the control and TPN + GLP-2 groups, intestinal cleaved caspase-3 was increased in the TPN group (all p < 0.05). This study shows GLP-2 reduces TPN-associated intestinal atrophy and improves tissue antioxidant capacity. This effect may be dependent on enhanced epithelial cell proliferation, reduced apoptosis, and upregulated GRP78 expression. View Full-Text
Keywords: glucagon-like peptide-2; antioxidant capacity; proliferation; apoptosis; GRP78 glucagon-like peptide-2; antioxidant capacity; proliferation; apoptosis; GRP78

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Lei, Q.; Bi, J.; Wang, X.; Jiang, T.; Wu, C.; Tian, F.; Gao, X.; Wan, X.; Zheng, H. GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition. Nutrients 2016, 8, 33.

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