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Regulation of Dendritic Cell Function by Vitamin D

by Myriam Barragan 1,2,3,†, Misty Good 1,3,4,† and Jay K. Kolls 1,3,*
1
Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
2
Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
3
Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA
4
Division of Newborn Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(9), 8127-8151; https://doi.org/10.3390/nu7095383
Received: 29 July 2015 / Revised: 4 September 2015 / Accepted: 10 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health. View Full-Text
Keywords: vitamin D; vitamin D receptor; dendritic cells; innate and adaptive immunity; interleukins; cytokines; inflammation vitamin D; vitamin D receptor; dendritic cells; innate and adaptive immunity; interleukins; cytokines; inflammation
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Barragan, M.; Good, M.; Kolls, J.K. Regulation of Dendritic Cell Function by Vitamin D. Nutrients 2015, 7, 8127-8151.

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