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Open AccessArticle

Effects of Fuzhuan Brick-Tea Water Extract on Mice Infected with E. coli O157:H7

by Yuanliang Wang 1,2, Aiqing Xu 1,3, Ping Liu 1 and Zongjun Li 1,2,4,*
College of Food Science and Technology, Hunan Agriculture University, Changsha 410128, China
Hunan Province Key Laboratory of Food and Biotechnology, Changsha 410128, China
School of Life Science, Hunan University of Science and Technology, Xiangtan 411201, China
Functional Food Sub-center, National Research Center of Engineering &Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5309-5326;
Received: 5 February 2015 / Revised: 17 April 2015 / Accepted: 25 May 2015 / Published: 1 July 2015
Fuzhuan brick-tea extract (FBTE) affects the physiology of mice infected with Escherichia coli O157:H7. For 10 consecutive days, 0.05, 0.5, and 1.0 g/mL FBTE was administered intragastrically to three groups of infected Kunming mice, and changes in immunological function, hematology, and histopathology were examined. The results revealed upregulation of platelets, total protein, and albumin along with downregulation of serum triglycerides, aspartate aminotransferase, creatinine, and urea nitrogen in FBTE-treated mice. Histological sections of stomach, kidney, duodenum, ileum, and colon suggested that infected mucous membranes could be rehabilitated by low- and high-dose FBTE and that inflammation was alleviated. Similarly, increased thymic function in mice treated with middle- and high-dose FBTE led to elevated serum hemolysin antibody titer and increased CD4+ and CD8+ T cells, as indicated by CD4+ and CD8+ expression on intestinal mucosa. Monocyte and macrophage function was improved by three FBTE dosages tested. Colonic microbiota analysis by denaturing gradient gel electrophoresis (DGGE) revealed characteristic bands in infected mice treated with middle- and high-dose FBTE and increased species diversity in Lactobacillus, Bacteroides, and Clostridium cluster IV. These results suggest that FBTE may protect kidney and liver of mice infected with E. coli O157:H7, improve immune function, and regulate the colonic microbiota. View Full-Text
Keywords: Fuzhuan brick-tea; E. coli O157:H7; immunologic function; colonic microbiota; function Fuzhuan brick-tea; E. coli O157:H7; immunologic function; colonic microbiota; function
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Wang, Y.; Xu, A.; Liu, P.; Li, Z. Effects of Fuzhuan Brick-Tea Water Extract on Mice Infected with E. coli O157:H7. Nutrients 2015, 7, 5309-5326.

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