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Open AccessArticle

Effect of Stay-Green Wheat, a Novel Variety of Wheat in China, on Glucose and Lipid Metabolism in High-Fat Diet Induced Type 2 Diabetic Rats

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Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Department of Public Health, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China
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Cardiovascular Research Center, Xi'an Jiaotong University, Xi'an 710061, China
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Medical College, Yan'an University, Yan'an 716000, China
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Shaanxi Key laboratory of Degradable Biomedical Materials, Department of Food Science and Engineering, College of Chemical Engineering, Northwest University, Xi'an 710069, China
*
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5143-5155; https://doi.org/10.3390/nu7075143
Received: 20 February 2015 / Revised: 3 June 2015 / Accepted: 11 June 2015 / Published: 26 June 2015
The use of natural hypoglycemic compounds is important in preventing and managing Type 2 diabetes mellitus (T2DM). Forty male Sprague-Dawley rats weighing 150–180 g were divided into four groups to investigate the effects of the compounds in stay-green wheat (SGW), a novel variety of wheat in China, on T2DM rats. The control group (NDC) was fed with a standard diet, while T2DM was induced in the rats belonging to the other three groups by a high-fat diet followed by a streptozotocin (STZ) injection. The T2DM rats were further divided into a T2DM control group (DC), which was fed with the normal diet containing 50% common wheat flour, a high dose SGW group (HGW) fed with a diet containing 50% SGW flour, and a low dose SGW group (LGW) fed with a diet containing 25% SGW flour and 25% common wheat flour. Our results showed that SGW contained cereal antioxidants, particularly high in flavonoids and anthocyanins (46.14 ± 1.80 mg GAE/100 g DW and 1.73 ± 0.14 mg CGE/100 g DW, respectively). Furthermore, SGW exhibited a strong antioxidant activity in vitro (30.33 ± 2.66 μg TE/g DW, p < 0.01). Administration of the SGW at a high and low dose showed significant down-regulatory effects on fasting blood glucose (decreasing by 11.3% and 7.0%, respectively), insulin levels (decreasing by 12.3% and 9.7%, respectively), and lipid status (decreasing by 9.1% and 7.5%, respectively) in T2DM rats (p < 0.01). In addition, the T2DM groups treated with SGW at a high and low dose showed a significant increase in the blood superoxide dismutase (1.17 fold and 1.15 fold, respectively) and glutathione peroxidase activities (1.37 fold and 1.30 fold, respectively) compared with the DC group (p < 0.01). The normalized impaired antioxidant status of the pancreatic islet and of the liver compared with the DC group was also significantly increased. Our results indicated that SGW components exerting a glycemic control and a serum lipid regulation effect may be due to their free radical scavenging capacities to reduce the risk of T2DM in experimental diabetic rats. View Full-Text
Keywords: stay-green wheat; type 2 diabetic mellitus; high-fat diet; antioxidant activities stay-green wheat; type 2 diabetic mellitus; high-fat diet; antioxidant activities
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Ji, J.; Zhang, C.; Luo, X.; Wang, L.; Zhang, R.; Wang, Z.; Fan, D.; Yang, H.; Deng, J. Effect of Stay-Green Wheat, a Novel Variety of Wheat in China, on Glucose and Lipid Metabolism in High-Fat Diet Induced Type 2 Diabetic Rats. Nutrients 2015, 7, 5143-5155.

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