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Open AccessArticle

Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats

1
Department of Anatomy, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand
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Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand
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Department of Pharmacology, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5265-5280; https://doi.org/10.3390/nu7075222
Received: 17 May 2015 / Revised: 17 June 2015 / Accepted: 23 June 2015 / Published: 30 June 2015
The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-l-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47phox expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47phox expression, which prevents oxidative stress and restores NO bioavailability. View Full-Text
Keywords: ellagic acid; high blood pressure; nitric oxide deficiency; NADPH oxidase; antioxidant ellagic acid; high blood pressure; nitric oxide deficiency; NADPH oxidase; antioxidant
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Berkban, T.; Boonprom, P.; Bunbupha, S.; Welbat, J.U.; Kukongviriyapan, U.; Kukongviriyapan, V.; Pakdeechote, P.; Prachaney, P. Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. Nutrients 2015, 7, 5265-5280.

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