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Open AccessArticle

Caffeine Affects Time to Exhaustion and Substrate Oxidation during Cycling at Maximal Lactate Steady State

1
Santa Catarina State University, Human Performance Research Group, Rua Pascoal Simone, 358, Coqueiros, Florianópolis, Santa Catarina 88080-350, Brazil
2
Federal University of Santa Catarina, Physical Effort Laboratory, Pantanal, Florianópolis, Santa Catarina 88040-900, Brazil
3
Abt. Medizin, Training und Gesundheit, Inst. Sportwissenschaft und Motologie, Philipps Universität Marburg, Marburg 35037, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5254-5264; https://doi.org/10.3390/nu7075219
Received: 1 May 2015 / Revised: 8 June 2015 / Accepted: 15 June 2015 / Published: 30 June 2015
This study analyzed the effects of caffeine intake on whole-body substrate metabolism and exercise tolerance during cycling by using a more individualized intensity for merging the subjects into homogeneous metabolic responses (the workload associated with the maximal lactate steady state—MLSS). MLSS was firstly determined in eight active males (25 ± 4 years, 176 ± 7 cm, 77 ± 11 kg) using from two to four constant-load tests of 30 min. On two following occasions, participants performed a test until exhaustion at the MLSS workload 1 h after taking either 6 mg/kg of body mass of caffeine or placebo (dextrose), in a randomized, double-blinded manner. Respiratory exchange ratio was calculated from gas exchange measurements. There was an improvement of 22.7% in time to exhaustion at MLSS workload following caffeine ingestion (95% confidence limits of ±10.3%, p = 0.002), which was accompanied by decrease in respiratory exchange ratio (p = 0.001). These results reinforce findings indicating that sparing of the endogenous carbohydrate stores could be one of the several physiological effects of caffeine during submaximal performance around 1 h. View Full-Text
Keywords: fat metabolism; submaximal performance; muscle glycogen; endurance fat metabolism; submaximal performance; muscle glycogen; endurance
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Cruz, R.S.O.; De Aguiar, R.A.; Turnes, T.; Guglielmo, L.G.A.; Beneke, R.; Caputo, F. Caffeine Affects Time to Exhaustion and Substrate Oxidation during Cycling at Maximal Lactate Steady State. Nutrients 2015, 7, 5254-5264.

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