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Open AccessArticle

Caffeine Affects Time to Exhaustion and Substrate Oxidation during Cycling at Maximal Lactate Steady State

Santa Catarina State University, Human Performance Research Group, Rua Pascoal Simone, 358, Coqueiros, Florianópolis, Santa Catarina 88080-350, Brazil
Federal University of Santa Catarina, Physical Effort Laboratory, Pantanal, Florianópolis, Santa Catarina 88040-900, Brazil
Abt. Medizin, Training und Gesundheit, Inst. Sportwissenschaft und Motologie, Philipps Universität Marburg, Marburg 35037, Germany
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5254-5264;
Received: 1 May 2015 / Revised: 8 June 2015 / Accepted: 15 June 2015 / Published: 30 June 2015
This study analyzed the effects of caffeine intake on whole-body substrate metabolism and exercise tolerance during cycling by using a more individualized intensity for merging the subjects into homogeneous metabolic responses (the workload associated with the maximal lactate steady state—MLSS). MLSS was firstly determined in eight active males (25 ± 4 years, 176 ± 7 cm, 77 ± 11 kg) using from two to four constant-load tests of 30 min. On two following occasions, participants performed a test until exhaustion at the MLSS workload 1 h after taking either 6 mg/kg of body mass of caffeine or placebo (dextrose), in a randomized, double-blinded manner. Respiratory exchange ratio was calculated from gas exchange measurements. There was an improvement of 22.7% in time to exhaustion at MLSS workload following caffeine ingestion (95% confidence limits of ±10.3%, p = 0.002), which was accompanied by decrease in respiratory exchange ratio (p = 0.001). These results reinforce findings indicating that sparing of the endogenous carbohydrate stores could be one of the several physiological effects of caffeine during submaximal performance around 1 h. View Full-Text
Keywords: fat metabolism; submaximal performance; muscle glycogen; endurance fat metabolism; submaximal performance; muscle glycogen; endurance
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Cruz, R.S.O.; De Aguiar, R.A.; Turnes, T.; Guglielmo, L.G.A.; Beneke, R.; Caputo, F. Caffeine Affects Time to Exhaustion and Substrate Oxidation during Cycling at Maximal Lactate Steady State. Nutrients 2015, 7, 5254-5264.

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