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Differential Acute Effects of Selenomethionine and Sodium Selenite on the Severity of Colitis

German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
Author to whom correspondence should be addressed.
Nutrients 2015, 7(4), 2687-2706;
Received: 22 February 2015 / Revised: 26 March 2015 / Accepted: 31 March 2015 / Published: 10 April 2015
(This article belongs to the Special Issue Dietary Selenium and Human Health)
The European population is only suboptimally supplied with the essential trace element selenium. Such a selenium status is supposed to worsen colitis while colitis-suppressive effects were observed with adequate or supplemented amounts of both organic selenomethionine (SeMet) and inorganic sodium selenite. In order to better understand the effect of these selenocompounds on colitis development we examined colonic phenotypes of mice fed supplemented diets before the onset of colitis or during the acute phase. Colitis was induced by treating mice with 1% dextran sulfate sodium (DSS) for seven days. The selenium-enriched diets were either provided directly after weaning (long-term) or were given to mice with a suboptimal selenium status after DSS withdrawal (short-term). While long-term selenium supplementation had no effect on colitis development, short-term selenite supplementation, however, resulted in a more severe colitis. Colonic selenoprotein expression was maximized in all selenium-supplemented groups independent of the selenocompound or intervention time. This indicates that the short-term selenite effect appears to be independent from colonic selenoprotein expression. In conclusion, a selenite supplementation during acute colitis has no health benefits but may even aggravate the course of disease. View Full-Text
Keywords: selenomethionine; selenite; colitis; IBD; DSS; oxidative stress selenomethionine; selenite; colitis; IBD; DSS; oxidative stress
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Hiller, F.; Oldorff, L.; Besselt, K.; Kipp, A.P. Differential Acute Effects of Selenomethionine and Sodium Selenite on the Severity of Colitis. Nutrients 2015, 7, 2687-2706.

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