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B Vitamins, Homocysteine and Bone Health

Department of Surgery and Traslational Medicine, University of Florence, Viale Pieraccini, 6-50139 Florence, Italy
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Nutrients 2015, 7(4), 2176-2192; https://doi.org/10.3390/nu7042176
Received: 19 December 2014 / Revised: 16 February 2015 / Accepted: 12 March 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Nutrition and Bone Health)
Nutrition is one of the most important modifiable factors involved in the development and maintenance of good bone health. Calcium and Vitamin D have confirmed and established roles in the maintenance of proper bone health. However, other nutritional factors could also be implicated. This review will explore the emerging evidence of the supporting role of certain B Vitamins as modifiable factors associated with bone health. Individuals with high levels of homocysteine (hcy) exhibit reduced bone mineral density (BMD), alteration in microarchitecture and increased bone fragility. The pathophysiology caused by high serum homocysteine is not completely clear regarding fractures, but it may involve factors, such as bone mineral density, bone turnover, bone blood flow and collagen cross-linking. It is uncertain whether supplementation with B Vitamins, such as folate, Vitamin B1, and Vitamin B6, could decrease hip fracture incidence, but the results of further clinical trials should be awaited before a conclusion is drawn. View Full-Text
Keywords: B Vitamins; folate; homocysteine; plasma total homocysteine (tHcy); methylene tetrahydrofolate reductase (MTHFR); MTHFR 677C_T polymorphism; fracture; bone B Vitamins; folate; homocysteine; plasma total homocysteine (tHcy); methylene tetrahydrofolate reductase (MTHFR); MTHFR 677C_T polymorphism; fracture; bone
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Fratoni, V.; Brandi, M.L. B Vitamins, Homocysteine and Bone Health. Nutrients 2015, 7, 2176-2192.

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