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Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy

1
Centre for Chronic Disease, College of Health & Biomedicine, Victoria University, Melbourne 8001, Australia
2
Institute of Sport, Exercise & Healthy Living, Victoria University, Melbourne 8001, Australia
3
Australian Institute of Musculoskeletal Science, Western Health, Melbourne 3021, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(12), 9734-9767; https://doi.org/10.3390/nu7125498
Received: 26 August 2015 / Revised: 29 October 2015 / Accepted: 13 November 2015 / Published: 26 November 2015
Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease. View Full-Text
Keywords: Duchenne Muscular Dystrophy; metabolism; mitochondria; nutriceuticals; dietary supplementation Duchenne Muscular Dystrophy; metabolism; mitochondria; nutriceuticals; dietary supplementation
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Rybalka, E.; Timpani, C.A.; Stathis, C.G.; Hayes, A.; Cooke, M.B. Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy. Nutrients 2015, 7, 9734-9767.

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