Estimation of 24-Hour Urinary Sodium Excretion Using Spot Urine Samples
AbstractThe present study evaluated the reliability of equations using spot urine (SU) samples in the estimation of 24-hour urine sodium excretion (24-HUNa). Equations estimating 24-HUNa from SU samples were derived from first-morning SU of 101 participants (52.4 ± 11.1 years, range 24–70 years). Equations developed by us and other investigators were validated with SU samples from a separate group of participants (n = 224, 51.0 ± 10.9 years, range 24–70 years). Linear, quadratic, and cubic equations were derived from first-morning SU samples because these samples had a sodium/creatinine ratio having the highest correlation coefficient for 24-HUNa/creatinine ratio (r = 0.728, p < 0.001). In the validation group, the estimated 24-HUNa showed significant correlations with measured 24-HUNa values. The estimated 24-HUNa by the linear, quadratic, and cubic equations developed from our study were not significantly different from measured 24-HUNa, while estimated 24-HUNa by previously developed equations were significantly different from measured 24-HUNa values. The limits of agreement between measured and estimated 24-HUNa by six equations exceeded 100 mmol/24-hour in the Bland-Altman analysis. All equations showed a tendency of under- or over-estimation of 24-HUNa, depending on the level of measured 24-HUNa. Estimation of 24-HUNa from single SU by equations as tested in the present study was found to be inadequate for the estimation of an individual’s 24-HUNa. View Full-Text
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Rhee, M.-Y.; Kim, J.-H.; Shin, S.-J.; Gu, N.; Nah, D.-Y.; Hong, K.-S.; Cho, E.-J.; Sung, K.-C. Estimation of 24-Hour Urinary Sodium Excretion Using Spot Urine Samples. Nutrients 2014, 6, 2360-2375.
Rhee M-Y, Kim J-H, Shin S-J, Gu N, Nah D-Y, Hong K-S, Cho E-J, Sung K-C. Estimation of 24-Hour Urinary Sodium Excretion Using Spot Urine Samples. Nutrients. 2014; 6(6):2360-2375.Chicago/Turabian Style
Rhee, Moo-Yong; Kim, Ji-Hyun; Shin, Sung-Joon; Gu, Namyi; Nah, Deuk-Young; Hong, Kyung-Soon; Cho, Eun-Joo; Sung, Ki-Chul. 2014. "Estimation of 24-Hour Urinary Sodium Excretion Using Spot Urine Samples." Nutrients 6, no. 6: 2360-2375.