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Nutrients 2014, 6(6), 2348-2359; https://doi.org/10.3390/nu6062348

Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial

1
Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, France
2
Seppic Company, 22 Terasse Bellini, Puteaux 92806, France
3
Therapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, 2 rue Ambroise-Paré, Paris 75010, France
*
Author to whom correspondence should be addressed.
Received: 10 February 2014 / Revised: 23 May 2014 / Accepted: 3 June 2014 / Published: 19 June 2014
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Abstract

Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922. View Full-Text
Keywords: psychological stress; physical and mental fatigue; oxidative stress; melon; superoxide dismutase; psychometric scales psychological stress; physical and mental fatigue; oxidative stress; melon; superoxide dismutase; psychometric scales
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Carillon, J.; Notin, C.; Schmitt, K.; Simoneau, G.; Lacan, D. Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial. Nutrients 2014, 6, 2348-2359.

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