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Open AccessArticle

25-Hydroxyvitamin D and Its Relationship with Autonomic Dysfunction Using Time- and Frequency-Domain Parameters of Heart Rate Variability in Korean Populations: A Cross-Sectional Study

1
Department of Family Medicine, Pusan National University School of Medicine, 602-739 Busan, Korea
2
Biomedical Research Institute, Pusan National University Hospital, 602-739 Busan, Korea
3
Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, 626-870 Yangsan, Korea
4
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National Yangsan Hospital, 626-789 Yangsan, Korea
5
Department of Preventive Medicine and Occupational Medicine, Pusan National University School of Medicine, 626-770 Yangsan, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2014, 6(10), 4373-4388; https://doi.org/10.3390/nu6104373
Received: 30 July 2014 / Revised: 28 August 2014 / Accepted: 24 September 2014 / Published: 16 October 2014
(This article belongs to the Special Issue Nutrition and CVD)
Previous studies have demonstrated that reduced heart rate variability (HRV) and hypovitaminosis D are associated with cardiovascular disease (CVD). However, few reports have investigated the effects of vitamin D on HRV. This cross-sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and HRV indices using 5-min R-R interval recordings with an automatic three-channel electrocardiography in healthy subjects (103 males and 73 females). Standard deviation of N-N interval (SDNN), square root of mean squared differences of successive N-N intervals (RMSSD), total power (TP), very low frequency (VLF), low frequency (LF), and high frequency (HF) were reported. The mean age of subjects was 55.3 ± 11.3 years and the mean 25(OH)D level was 21.2 ± 9.9 ng/mL. In a multiple linear regression model, 25(OH)D was positively correlated with SDNN (β = 0.240, p < 0.002), and LF (β = 0.144, p = 0.044). Vitamin D deficiency (25(OH)D < 15 ng/mL) was associated with decreased SDNN (<30 m/s) (OR, 3.07; 95% confidence interval (CI), 1.32–7.14; p = 0.014) after adjusting for covariates. We found that lower 25(OH)D levels were associated with lower HRV, suggesting a possible explanation for the higher risk of CVD in populations with hypovitaminosis D. View Full-Text
Keywords: heart rate variability; vitamin D; 25-hydroxyvitamin D heart rate variability; vitamin D; 25-hydroxyvitamin D
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Tak, Y.J.; Lee, J.G.; Kim, Y.J.; Lee, S.Y.; Cho, B.M. 25-Hydroxyvitamin D and Its Relationship with Autonomic Dysfunction Using Time- and Frequency-Domain Parameters of Heart Rate Variability in Korean Populations: A Cross-Sectional Study. Nutrients 2014, 6, 4373-4388.

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