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Nutrients 2013, 5(9), 3531-3550;

Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models

Department of Human Genetics, McGill University, 1205 Avenue Docteur Penfield, N5/13,Montreal, Quebec, Canada H3A 1B1
Department of Pediatrics, McGill University, Montreal, Quebec, Canada H3H 1P3
McGill University Health Centre, 4060 Ste. Catherine West, PT 420, Montreal, Quebec, Canada H3Z 2Z3
Author to whom correspondence should be addressed.
Received: 5 July 2013 / Revised: 10 August 2013 / Accepted: 23 August 2013 / Published: 10 September 2013
(This article belongs to the Special Issue Vitamin B12 and Human Health)
Full-Text   |   PDF [269 KB, uploaded 10 September 2013]


Vitamin B12 (cobalamin, Cbl) is required for cellular metabolism. It is an essential coenzyme in mammals for two reactions: the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of methylmalonyl-CoA to succinyl-CoA by the enzyme methylmalonyl-CoA mutase. Symptoms of Cbl deficiency are hematological, neurological and cognitive, including megaloblastic anaemia, tingling and numbness of the extremities, gait abnormalities, visual disturbances, memory loss and dementia. During pregnancy Cbl is essential, presumably because of its role in DNA synthesis and methionine synthesis; however, there are conflicting studies regarding an association between early pregnancy loss and Cbl deficiency. We here review the literature about the requirement for Cbl during pregnancy, and summarized what is known of the expression pattern and function of genes required for Cbl metabolism in embryonic mouse models. View Full-Text
Keywords: cobalamin; mouse models; development; metabolism; vitamin B12 cobalamin; mouse models; development; metabolism; vitamin B12
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Moreno-Garcia, M.A.; Rosenblatt, D.S.; Jerome-Majewska, L.A. Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models. Nutrients 2013, 5, 3531-3550.

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